Trypsin Inhibitor, soybeanAn inhibitor of trypsin factor Xa, plasmin and neutrophil elastase

Trypsin Inhibitor, soybean (CAS 9035-81-8)

Trypsin Inhibitor, soybean | CAS 9035-81-8 is rated 5.0 out of 5 by 1.
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Synonym: SBTI; Trypsin inhibitor from Glycine max
Application: An inhibitor of trypsin factor Xa, plasmin and neutrophil elastase
CAS Number: 9035-81-8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Soybean trypsin inhibior (STI) is a protein which reduces trypsin (a proteolytic enzyme) as well as plasma kallikrein, factor Xa and plasmin activity. Soybean trypsin inhibitor has demonstrated inhibition of human neutrophil elastase at an IC50=0.3 nM. At this concentration soybean trypsin inhibitor showed neither cytotoxic nor haemolytic effects on populations of human blood cells. In fibrin matrix, and without toxic effects, STI had a strong inhibitory effect on human umbilical vein endothelial cells migration and tubulogenesis.


References

1. Wilson, P.A., et al. 1978. Gut. 19: 260-266. PMID: 348580
2. Shakiba, Y., et al. 2007. Fitoterapia. 78: 587-589. PMID: 17590534
3. Ribeiro, J.K., et al. 2010. Eur J Pharmacol. PMID: 20624384

Appearance :
powder
Physical State :
Solid
Derived From :
Soy Bean
Solubility :
Soluble in water (10 mg/ml), phosphate buffers (10 mg/ml), and balanced salt solutions (1 mg/ml).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
MDL Number :
MFCD00082103
EC Number :
232-906-9

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Trypsin Inhibitor, soybean  Product Citations

See how others have used Trypsin Inhibitor, soybean. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 12 total

PMID: # 18466892  Psenicka, M. et al. 2008. Cryobiology. 56: 251-253.

PMID: # 17640870  Conners, R. et al. 2007. J. Biol. Chem. 282: 27760-27768.

PMID: # 17171473  Oshima, K. et al. 2007. J. Assoc. Res. Otolaryngol. 8: 18-31.

PMID: # 16982799  Csordás, G. et al. 2006. J. Cell Biol. 174: 915-921.

PMID: # 16319066  Harikumar, KG. et al. 2006. J. Biol. Chem. 281: 2543-2550.

PMID: # 16228192  Wang, KJ. et al. 2005. Theor. Appl. Genet. 112: 66-71.

PMID: # 15644453  Taylor, EB. et al. 2005. Am. J. Physiol. Endocrinol. Metab. 288: E1055-E1061.

PMID: # 15382080  Kobayashi, H. et al. 2004. Int. J. Cancer. 112: 519-524.

PMID: # 14726309  Patil, SB. et al. 2004. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G954-63.

PMID: # 15168733  Kobayashi, H. et al. 2004. Clin. Exp. Metastasis. 21: 159-166.

Citations 1 to 10 of 12 total
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Rated 5 out of 5 by from Kobayashi Kobayashi, et. al. (PubMed ID 15168733) used soy bean trypsin inhibitor to study its effect on enzymatic activity of secreted, extracellular uPA. -SCBT Publication Review
Date published: 2015-03-20
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