Trolox An antioxidant derived from water-soluble vitamin E

Trolox (CAS 53188-07-1)

Trolox | CAS 53188-07-1 is rated 5.0 out of 5 by 1.
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| See product citations (13)
Synonym: 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Application: An antioxidant derived from water-soluble vitamin E
CAS Number: 53188-07-1
Purity: ≥97%
Molecular Weight: 250.29
Molecular Formula: C14H18O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Trolox sc-200810 500 mg $25.00
Trolox sc-200810A 1 g $60.00
Trolox sc-200810B 5 g $216.00
Trolox sc-200810C 25 g $640.00
Trolox sc-200810D 100 g $1,600.00

Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid (sc-204753) and p-coumaric acid (sc-215648). Studies show that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It has been observed that Trolox can quench free radicals and inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii.


References

1. Pannala, A.S., et al. 1998. Free Radic. Biol. Med. 24: 594-606. PMID: 9559872

2. Brookes, P.S., et al. 1998. J. Neurochem. 70: 2195-2202. PMID: 9572308

3. Chen, Q. and Cederbaum, A.I. 1998. Mol. Pharmacol. 53: 638-648. PMID: 9547353

4. Bian, X. et al. 2001. J. Biol. Chem. 276(52): 48921-48929. PMID: 11679590

5. Cuperus, R. et al. 2008. Int. J. Oncol. 32(5): 1011-1019. PMID: 18425327

6. Jung, M.Y. and Min, D.B. 2009. J. Food Sci. 74: C449-C455. PMID: 19723181

7. Ruebhart, D.R., et al. 2009. J. Toxicol. Environ. Health Part A. 72: 1567-1575. PMID: 20077231

8. Kaur, P., et al. 2010. Toxicology. 276: 73-78. PMID: 20637824

9. Mitchell, R.M. et al. 2011. Neurobiol. Aging. 32(6): 1114-1123. PMID: 19560233

10. Okamoto, A. et al. 2016. BMC Anesthesiol. 16(1): 104. PMID: 27776485

Physical State :
Solid
Solubility :
Soluble in 100% ethanol (25 mg/ml), methanol, water(slightly), DMSO (~20 mg/ml), DMF (~20 mg/ml), and PBS( pH7.2) (~3 mg/ml).
Storage :
Store at -20° C
Melting Point :
187-189° C
Boiling Point :
~405.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.57
IC50 :
Rattus norvegicus: EC5050 = 77.8 µM; COX2: IC50 = 150 nM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 3.6 µM (human); Bos taurus: IC50 = 5 µM; COX1: IC50 = 130 nM (human); Rattus norvegicus: IC50 = 14 µM; Brain: IC50 = 41.57 µM (Rattus norvegicus); MCF7 (Breast carcinoma cells): IC50 = 1461 µM (human); Radical scavenging activity: IC50 = 10.6 µM
pK Values :
pKa: 3.35
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DJ2273000
PubChem CID :
40634
MDL Number :
MFCD00006846
EC Number :
258-422-8
Beilstein Registry :
1384051
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)O)C)O

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Certificate of Analysis

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TroloxProduct Citations

See how others have used Trolox. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 28223427  Noguchi, F. et al. 2017. Mol. Cancer Ther. 16: 936-947.

PMID: # 28887471  Tang, J. et al. 2017. Sci Rep. 7: 10945.

PMID: # 29162859  Kondratskyi, A. et al. 2017. Sci Rep. 7: 15896.

PMID: # 27383327  2016. Eur Rev Med Pharmacol Sci. 20: 2710-7.

PMID: # 26200654  Penzo-Méndez, AI. et al. 2015. PloS one. 10: e0132437.

PMID: # 25842615  McDonald, JD. et al. 2015. Research report (Health Effects Institute). 9-44; discussion 141-71.

PMID: # 25301069  Skliris, A. et al. 2015. Cell Death Differ. 22: 703-18.

PMID: # 23902736  Rico-Bautista, E. et al. 2013. Oncotarget. 4: 1212-29.

PMID: # 21939437  Guo, C. et al. 2012. Cell biology international. 36: 183-8.

PMID: # 18442981  Chen, WY. et al. 2008. J. Biol. Chem. 283: 17184-17193.

Citations 1 to 10 of 13 total

Could you tell me, at which doses Trolox is used as a antioxidant to SH-SY5Y or IMR 32 cells, please?

Asked by: Nelly22
Thank you for your question. Here are a few citations that discuss this with those cells. Bian, X. et al. 2001. J. Biol. Chem. 276(52): 48921-48929. PMID: 11679590 Cuperus, R. et al. 2008. Int. J. Oncol. 32(5): 1011-1019. PMID: 18425327 Mitchell, R.M. et al. 2011. Neurobiol. Aging. 32(6): 1114-1123. PMID: 19560233 Okamoto, A. et al. 2016. BMC Anesthesiol. 16(1): 104. PMID: 27776485 If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-08-30

Me mandarian la cotizacion por favor

Asked by: Raquel ss
Por favor comuníquese con nuestro distribuidor autorizado en Peru para recibir un presupuesto. https://www.scbt.com/scbt/resources/distributors Please contact our authorized distributor in Peru to receive a quote. https://www.scbt.com/scbt/resources/distributors
Answered by: Tech Service 3
Date published: 2017-05-24

HOLA BUENAS NOCHES.. me podrian mandar la cotización por favor. 

Asked by: RAQUEL SS
Por favor comuníquese con nuestro distribuidor autorizado en Peru para recibir un presupuesto. https://www.scbt.com/scbt/resources/distributors Please contact our authorized distributor in Peru to receive a quote. https://www.scbt.com/scbt/resources/distributors
Answered by: Tech Service 3
Date published: 2017-05-24

Can this product be stored in solution?

Asked by: hawkeye11
Thank you for your question. We suggest to store the product as a solid in the original vial at -20ºC. Upon dissolution in ethanol/PBS, we recommend that you use the product within a day. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-20

LOS PRECIOS QUE MANEJAN ES EN DOLARES, EUROS O PESO MEXICANO??

Asked by: MARY MENDOZA
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Rated 5 out of 5 by from Chen Chen, et. al. (PubMed ID 18442981) reported that trolox, a non-thiol anti-oxidant, was not effective in preventing Hsp90 inhibition and cell death. -SCBT Publication Review
Date published: 2015-01-04
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