Troleandomycin Troleandomycin is a macrolide antibiotic that is a stronger inhibitor than Roxithromycin (sc-205845). This compound inhibits P450 and has been used in multiple asthma studies.

Troleandomycin  (CAS 2751-09-9)

Troleandomycin is rated 5.0 out of 5 by 1.
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| See 3 Citations
Synonym: Triacetyloleandomycinum
Application: A macrolide antibiotic and an inhibitor of CYP
CAS Number: 2751-09-9
Purity: ≥98%
Molecular Weight: 813.97
Molecular Formula: C41H67NO15
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

Troleandomycin sc-200747 10 mg $87.00
Troleandomycin sc-200747A 50 mg $374.00

Troleandomycin is a macrolide antibiotic. The compound is a stronger inhibitor of cytochrome P450 (P450 or CYP)-dependent drug oxidation when compared to roxithromycin (sc-205845). Cytochrome P450 has been shown to be involved in oxidizing N-omega-hydroxy-L-arginine through NADPH and O2 to nitric oxide and citrulline. Research shows that troleandomycin inhibits the release of nitric oxide from Glycerol trinitrate (GTN). Troleandomycin has been used in multiple asthma studies.


1. Weinberger, M., et al. 1977. J. Allergy Clin. Immunol. 59: 228-231. PMID: 300083
2. Zeiger, R.S., et al. 1980. J. Allergy Clin. Immunol. 66: 438-446. PMID: 6968762
3. Ludden, T.M. 1985. Clin Pharmacokinet. 10: 63-79. PMID: 3882305
4. Pollock, J.S., et al. 1993. Am. J. Physiol. 265: C1379-C1387. PMID: 7694497
5. Kozlov, A.V., et al. 2003. Br. J. Pharmacol. 139: 989-997. PMID: 12839873

Physical State :
Solubility :
Soluble in DMSO (50 mg/mL) and ethanol (25 mg/mL)
Storage :
Store at room temperature
Boiling Point :
812.49° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
MDL Number :
EC Number :
Beilstein Registry :

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Troleandomycin Product Citations

See how others have used Troleandomycin. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25152732
Manda, VK. et al. 2014. Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents. Front Pharmacol. 5: 178.

PMID: # 21622627
Fæste, CK. et al. 2011. In vitro metabolism of the mycotoxin enniatin B in different species and cytochrome p450 enzyme phenotyping by chemical inhibitors. Drug Metab. Dispos.. 39: 1768-76.

PMID: # 19410561
Dai, CL. et al. 2009. Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function. Biochem. Pharmacol.. 78: 355-364.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Dai Dai, et. al. (PubMed ID 19410561) treated liver microsomes (human) with Troleandomycin, a known inhibitor of CYP3A4, as a positive control for their CYP3A4 assay. -SCBT Publication Review
Date published: 2015-02-18
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