Tris-EDTA buffer solution is a formulation of 10 mM Tris-HCl, 1 mM disodium EDTA, pH 8.0.
Based on nuclease studies from the 1980's, the pH is usually adjusted to 7.5 for RNA and 8.0 for DNA. The respective DNA and RNA nucleases are supposed to be less active at these pH values, but pH 8.0 can safely be used for storage of both DNA and RNA.
EDTA further inactivates nucleases, by binding to metal ions required by these enzymes.
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