Triptolide

Triptolide (CAS 38748-32-2)

Triptolide | CAS 38748-32-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_7, d_17, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200122, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 55ms
  • REVIEWS, PRODUCT
Synonym: PG490
Application: An antiinflammatory immunosuppressive antibiotic
CAS Number: 38748-32-2
Purity: ≥98%
Molecular Weight: 360.4
Molecular Formula: C20H24O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Triptolide is a diterpene triepoxide antibiotic originally isolated from extracts of the herb Tripterygium wilfordii Hook F (TWHF). Triptolide has been shown to induce apoptosis of T lymphocytes by activating caspases, displaying an increase of DEVD-cleavable caspase activity correlated with the apoptosis. The proliferation of rheumatoid synovial fibroblasts characteristic of rheumatoid arthritis was similarly suppressed by treatment with Triptolide through an increase in caspase-3 activity. Cytokine gene expression in blood lymphocytes and T-cells are also suppressed by Triptolide, blocking the transcriptional activation of purine-box/antigen receptor response element/nuclear factor of activated T-cells (NF-AT) and of NF-kappaB.


References

1. Yang, Y., et al. 1998. Immunopharmacology. 40: 139-149. PMID: 9826028
2. Qiu, D., et al. 1999. J. Biol. Chem. 274: 13443-13450. PMID: 10224109
3. Kusunoki, N., et al. 2004. BMC Pharmacol. 4 :2. PMID: 15040811
4. Liacini, A., et al. 2005. Biochem. Biophys. Res. Commun. 327: 320-327. PMID: 15629465

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (1 mg/ml) (1h at 37°C).
Storage :
Store at -20° C
Melting Point :
235-237° C
Boiling Point :
~601.7° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.65
Optical Activity :
α25/D -205°, c = 0.2 in methanol
IC50 :
SK-OV-3 : IC50 = 6 nM (human); HCT-116: IC50 = 10 nM (human); A549: IC50 = 1.3 ng/ml (human); HT-29: IC50 = 0.1 ng/ml (human); KBM5 : IC50 = 8.3 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YK7751000
Transport :
UN 3462, Class 6.1, Packing group I
PubChem CID :
16220015
Merck Index :
14: 9747
MDL Number :
MFCD00210565
SMILES :
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C(C5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Triptolide  Product Citations

See how others have used Triptolide. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 29030393  Moriel-Carretero, M. et al. 2017. J. Cell Biol.

PMID: # 27239780  Wang, H. et al. 2016. Med. Sci. Monit. 22: 1827-36.

PMID: # 27422819  Donaubauer, EM. et al. 2016. J. Biol. Chem.

PMID: # 26859151  Boulding, T. et al. 2016. PloS one. 11: e0148065.

PMID: # 26329166  Ma, G. et al. 2015. Oncol. Rep. 34: 2423-30.

PMID: # 24820666  2014. Journal of dental research. 93: 678-84.

PMID: # 25009609  Shao, H. et al. 2014. Experimental and therapeutic medicine. 8: 505-508.

PMID: # 19893732  Koo, HS. et al. 2009. J Korean Neurosurg Soc. 46: 389-396.

Citations 1 to 9 of 9 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Triptolide, sc-200122, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-06-07
  • y_2019, m_7, d_17, h_1CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_200122, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 40ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Koo et al Koo et al. (PubMed ID 19893732) found Triptolide (TP) inhibited growth of HT22 hippocampal cells through constant ERK-1/2 activation by suppressing MKP-1 expression. -SCBT Publication Review
Date published: 2015-04-22
  • y_2019, m_7, d_17, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200122, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 57ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.