Trimethoprim is an antibacterial agent which selectively inhibits DHFR(dihydrofolate reductase) in prokaryotic microorganisms. in addition, trimethoprim is often combined with sulfamethoxazole (sc-208405) to inhibit the growth of Staphylococcus aureus. Studies suggest that electro-oxidation of trimethoprim is pH dependent and irreversible. Alternate studies show that trimethoprim can synergize with oxygen causing an increase in oxygen tensions in vitro, which decreases the minimal inhibitory concentrations of trimethoprim resulting in bactericidal effects.
1. Keck, P.E., et al. 1980. Undersea Biomed Res. 7: 95-106. PMID: 7404854 2. Rajith, L. and Kumar, K.G. 2010. Drug Test Anal. 2: 436-441. PMID: 20845390 3. Zander, J., et al. 2010. Int. J. Antimicrob. Agents. 36: 562-565. PMID: 20947313
Soluble in water (0.4 mg/ml), ethanol (2.6 mg/ml at 20° C), methanol (12.1 mg/ml), chloroform (22.2 mg/ml at 20° C), and DMSO (50 mg/ml).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Keck et alKeck et al. (PubMed ID 7404854) used trimethoprim as a sulfonamide potentiator that prevented an increase in oxygen levels and proved to be beneficial bactericidal and bacteriostatic in pathogenic bacteria. -SCBT Publication Review
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