Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Akt kinase inhibition has been shown to induce apoptosis and cell growth in cancer cell research. Triciribine can selectively inhibit Akt1, Akt2, and Akt3 without inhibiting known upstream activators,PDK1 and PI 3-Kinase, of Akt. Studies show that Triciribine in duces apoptosis and inhibits cell growth in cells that express atypical Akt1. Additionally, Triciribine has antineoplastic and antiviral activity at low micromolar and submicromolar concentrations, and has been demonstrated to inhibit incorporation of amino acids into proteins and purine nucleotide synthesis.
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See how others have used Triciribine. Click on the entry to view the PubMed entry .
PMID: # 26948085
Fu, T. et al. 2016. Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro. Acta Pharmacol. Sin.. 37: 505-18.
PMID: # 26159930
Feng, J. et al. 2015. Photoactivation of TAZ via Akt/GSK3β signaling pathway promotes osteogenic differentiation. Int. J. Biochem. Cell Biol.. 66: 59-68.
PMID: # 23946409
Meng, C. et al. 2013. Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease. J. Neurosci.. 33: 13505-17.
PMID: # 24023668
Liu, L. et al. 2013. Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. PLoS ONE. 8: e73038.
PMID: # 23065720
Huang, L. et al. 2013. Activation of nuclear estrogen receptors induced by low-power laser irradiation via PI3-K/Akt signaling cascade. J. Cell. Physiol.. 228: 1045-59.
PMID: # 22326662
Feng, J. et al. 2012. Low-power laser irradiation (LPLI) promotes VEGF expression and vascular endothelial cell proliferation through the activation of ERK/Sp1 pathway. Cell. Signal.. 24: 1116-1125.
PMID: # 22228808
Diraimondo, TR. et al. 2012. Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapy. J. Pharmacol. Exp. Ther.. 341: 104-14.
PMID: # 22917976
Liang, J. et al. 2012. Photobiomodulation by low-power laser irradiation attenuates Aβ-induced cell apoptosis through the Akt/GSK3β/β-catenin pathway. Free Radic. Biol. Med.. 53: 1459-67.
PMID: # 22705730
Jin, Y. et al. 2012. Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways. Acta Pharmacol. Sin.. 33: 861-72.
PMID: # 21505062
Kanai, R. et al. 2011. A novel oncolytic herpes simplex virus that synergizes with phosphoinositide 3-kinase/Akt pathway inhibitors to target glioblastoma stem cells. Clin. Cancer Res.. 17: 3686-96.
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