Triciribine Triciribine (also: API-2) is known to suppress the phosphorylation level and kinase activity of Akt. Selectively inhibits Akt1, Akt2, and Akt3 without inhibiting known upstream activators, PDK1 and PI 3-Kinase, of Akt.

Triciribine  (CAS 35943-35-2)

Triciribine is rated 5.0 out of 5 by 1.
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Synonym: API-2; NSC 154020; Tricyclic Nucleoside; Akt/PKB Signaling Inhibitor-2
Application: A tricyclic nucleoside that induces apoptosis and has antineoplastic and antiviral activity
CAS Number: 35943-35-2
Purity: ≥97%
Molecular Weight: 320.30
Molecular Formula: C13H16N6O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Triciribine sc-200661 1 mg $100.00
Triciribine sc-200661A 5 mg $180.00

Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Akt kinase inhibition has been shown to induce apoptosis and cell growth in cancer cell research. Triciribine can selectively inhibit Akt1, Akt2, and Akt3 without inhibiting known upstream activators,PDK1 and PI 3-Kinase, of Akt. Studies show that Triciribine in duces apoptosis and inhibits cell growth in cells that express atypical Akt1. Additionally, Triciribine has antineoplastic and antiviral activity at low micromolar and submicromolar concentrations, and has been demonstrated to inhibit incorporation of amino acids into proteins and purine nucleotide synthesis.


References

. Moore, E.C., et al. 1989. Biochem. Pharmacol. 38: 4037-4044. PMID: 2480791
2. Porcari, A.R., et al. 2000. J. Med. Chem. 43: 2438-2448. PMID: 10882371
3. Yang, L., et al. 2004. Cancer Res. 64: 4394-4399. PMID: 15231645

Physical State :
Solid
Solubility :
Soluble in 1eq. HCl (100 mM), and DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
216.02° C (Predicted)
Boiling Point :
~718.49° C at 760 mmHg (Predicted)
Density :
2.03 g/cm3 (Predicted)
Refractive Index :
n20D 1.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RY8455000
PubChem CID :
65399
SMILES :
CN1C2=NC=NC3=C2C(=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(=N1)N

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Certificate of Analysis

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Triciribine Product Citations

See how others have used Triciribine. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 26948085
Fu, T. et al. 2016. Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro. Acta Pharmacol. Sin.. 37: 505-18.

PMID: # 26159930
Feng, J. et al. 2015. Photoactivation of TAZ via Akt/GSK3β signaling pathway promotes osteogenic differentiation. Int. J. Biochem. Cell Biol.. 66: 59-68.

PMID: # 23946409
Meng, C. et al. 2013. Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease. J. Neurosci.. 33: 13505-17.

PMID: # 24023668
Liu, L. et al. 2013. Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. PLoS ONE. 8: e73038.

PMID: # 23065720
Huang, L. et al. 2013. Activation of nuclear estrogen receptors induced by low-power laser irradiation via PI3-K/Akt signaling cascade. J. Cell. Physiol.. 228: 1045-59.

PMID: # 22326662
Feng, J. et al. 2012. Low-power laser irradiation (LPLI) promotes VEGF expression and vascular endothelial cell proliferation through the activation of ERK/Sp1 pathway. Cell. Signal.. 24: 1116-1125.

PMID: # 22228808
Diraimondo, TR. et al. 2012. Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapy. J. Pharmacol. Exp. Ther.. 341: 104-14.

PMID: # 22917976
Liang, J. et al. 2012. Photobiomodulation by low-power laser irradiation attenuates Aβ-induced cell apoptosis through the Akt/GSK3β/β-catenin pathway. Free Radic. Biol. Med.. 53: 1459-67.

PMID: # 22705730
Jin, Y. et al. 2012. Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways. Acta Pharmacol. Sin.. 33: 861-72.

PMID: # 21505062
Kanai, R. et al. 2011. A novel oncolytic herpes simplex virus that synergizes with phosphoinositide 3-kinase/Akt pathway inhibitors to target glioblastoma stem cells. Clin. Cancer Res.. 17: 3686-96.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Moore et al Moore et al. (PuNMEd 2480791) found that triciribone inhibited purine synthesis in intact human leukemic lymphoblasts. -SCBT Publication Review
Date published: 2015-03-30
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