Trichloroacetic acid

Trichloroacetic acid (CAS 76-03-9)

Trichloroacetic acid | CAS 76-03-9 is rated 4.0 out of 5 by 1.
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Synonym: TCA
Application: An acetic acid analogue commonly used to precipitate proteins, DNA and RNA
CAS Number: 76-03-9
Purity: ≥99%
Molecular Weight: 163.39
Molecular Formula: C2HCl3O2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Trichloroacetic acid is an acetic acid analogue commonly used to precipitate proteins, DNA and RNA. In the presence of SDS (sc-24950) Trichloroacetic acid will precipitate proteins which can then be quantified by the Lowry method. The compound has also found uses as a decalcifier and fixative in microscopy, in protein sequencing, detecting albumin and organic synthesis. Rats exposed to chronic sublethal amounts of trichloroacetic acid displayed an increase in serum bilirubin with a decrease in hematological proteins and cholesterols along with significant decreases in red blood corpuscles, mean cell volume, mean corpuscular hemoglobin, hemoglobin and hematocrit. In mice the production of liver tumors was associated to Trichloroacetic acid, which is also a known mouse hepatocarinogen.


References

1. Cabib, E. and Polacheck, I. 1984. Meth. Enzymol. 104: 415-416. PMID: 6717293
2. Chang, Y.C. 1992. Anal. Biochem. 205: 22-26. PMID: 1443557
3. Celik, I. and Temur, A. 2009. Food Chem. Toxicol. 47: 1324-1326. PMID: 19286448
4. Rajalingam, D., et al. 2009. Protein Sci. 18: 980-993. PMID: 19388015
5. Sweeney, L.M., et al. 2009. Toxicology. 260: 77-83. PMID: 19464572

Physical State :
Solid
Solubility :
Soluble in water (1200 mg/ml at 20° C), alcohol, ether, ethanol (very soluble), and carbon tetrachloride.
Storage :
Desiccate at 4° C
Melting Point :
54-58° C
Boiling Point :
196° C
Density :
1.62 g/cm3 at 25° C
Refractive Index :
n20D 1.62 (lit.)
pK Values :
pKa: 0.09 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
AJ7875000
Transport :
UN 1839, Class 8, Packing group II
PubChem CID :
6421
Merck Index :
14: 9627
MDL Number :
MFCD00004177
EC Number :
200-927-2
Beilstein Registry :
970119
SMILES :
C(=O)(C(Cl)(Cl)Cl)O

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Certificate of Analysis

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Trichloroacetic acid  Product Citations

See how others have used Trichloroacetic acid. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 1443557  Chang, YC. et al. 1992. Anal. Biochem. 205: 22-26.

PMID: # 6717293  Cabib, E. et al. 1984. Meth. Enzymol. 104: 415-416.

Citations 1 to 2 of 2 total
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Date published: 2015-04-20
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