Triacsin C Solution in DMSO A hypotensive vasodilator, inhibitor of long-chain fatty acid acyl-CoA synthetase, neutrophils and β-cells

Triacsin C Solution in DMSO (CAS 76896-80-5)

Triacsin C Solution in DMSO | CAS 76896-80-5 is rated 5.0 out of 5 by 1.
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Synonym: 2,4,7-Undecatrienal nitrosohydrazone;WS1228A
Application: A hypotensive vasodilator, inhibitor of long-chain fatty acid acyl-CoA synthetase, neutrophils and β-cells
CAS Number: 76896-80-5
Purity: ≥90%
Molecular Weight: 207.27
Molecular Formula: C11H17N3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Triacsin C was originally isolated from a Streptomyces aureofaciens culture. The compound is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) in intact cells and the nonspecific ACSL in cell sonicates (IC50=3.6-8.7 μM). Triacsin C has been shown to inhibit de novo synthesis of triacylglycerol, diacylglycerol, cholesterol esters, and phospholipids. The inhibitory effect of Triacsin C prevents degranulation by human neutrophils through superoxide anion generation inhibition, thus inhibiting neutrophil activity. Triacsin C has been classified as a hypotensive vasodilator which may act by increasing methacholine-induced NO synthesis. The compound has also been reported to inhibit β-cells by abolishing L-type Ca2+ CP (L-type Ca2+) channel modulation.


References

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7. Tian, Y., et al. 2008. Am. J. Physiol. Endocrinol. Metab. 294: 1178-1186. PMID: 18430963

Usage :
NOTE: The product is not sterile.
Formulation :
1 mg/ml in DMSO
Physical State :
Liquid
Derived From :
Streptomyces aureofaciens
Solubility :
Soluble in DMSO (25 mg/ml), and methanol (5 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.49
IC50 :
nonspecific acyl-CoA synthetase: IC50 = 3.6-8.7 µM (cell sonicates)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9576787
MDL Number :
MFCD00798237
SMILES :
CCC/C=C/C/C=C/C=C/C=N/NN=O

Download SDS (MSDS)

Certificate of Analysis

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Triacsin C Solution in DMSO  Product Citations

See how others have used Triacsin C Solution in DMSO. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 26991015  Bando, M. et al. 2016. FEBS letters. 590: 992-1001.

PMID: # 26728854  Ohsaki, Y. et al. 2016. J. Cell Biol. 212: 29-38.

PMID: # 26282205  Kuwata, H. et al. 2015. Biochem. Biophys. Res. Commun. 465: 528-33.

PMID: # 25137547  Neuber, C. et al. 2014. Anal. Chem. 86: 9065-73.

PMID: # 23871243  Herms, A. et al. 2013. Current biology : CB. 23: 1489-96.

PMID: # 24368806  Kassan, A. et al. 2013. The Journal of cell biology. 203: 985-1001.

PMID: # 22675471  Li, H. et al. 2012. PLoS ONE. 7: e36712.

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

Citations 1 to 8 of 8 total
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Rated 5 out of 5 by from Tian et al Tian et al. (PubMed ID 18430963) used Triacsin C, an inhibitor of long-chain fatty acid acyl-CoA synthetase, to inactivate oleate potentiation of the Cav1.2 L-type calcium channel. -SCBT Publication Review
Date published: 2015-06-15
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