Tranilast Tranilast is an angiogenesis inhibitor that also inhibits the release of histamine and prostaglandins from basophils and mast cells.

Tranilast  (CAS 53902-12-8)

Tranilast is rated 5.0 out of 5 by 1.
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| See 1 Citations
Synonym: N-(3,4-Dimethoxycinnamoyl)anthranilic Acid; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid
Application: An inhibitor of angiogenesis and the release of histamine and prostaglandins
CAS Number: 53902-12-8
Purity: ≥98%
Molecular Weight: 327.33
Molecular Formula: C18H17NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Tranilast sc-200389 10 mg $29.00
Tranilast sc-200389A 50 mg $99.00

Tranilast is an angiogenesis inhibitor that also inhibits the release of histamine and prostaglandins from basophils and mast cells. Other functions of Tranilast include the ability to inhibit leukotrienes, oxygen radicals, cyclooxygenase-2 expression, cytokines, collagen synthesis, and blocks the production of IL-1 and IL-2 from human T-cells and macrophages. Studies indicate that Tranilast blocks vascular inflammation and disrupts the NF-κB/CBP interaction, which leads to the inhibition of NF-κB dependent transcription activation. Additionally, Tranilast has been reported to inhibit the release of PGE2 and TGF-β from monocytes-macrophages and the transformation of fibroblasts to myofibroblasts, and contraction in vitro. Smooth muscle cell studies have revealed that Tranilast inhibits vascular smooth muscle cell growth, calcium entry, and acts as an antagonist of Angiotensin (angiotensin II).


References

1. Suzawa, H., et al. 1992. Jpn. J. Pharmacol. 60: 85-90. PMID: 1282575
2. Yamada, H., et al. 1994. J. Biochem. 116: 892-897. PMID: 7533764
3. Isaji, M., et al. 1997. Br. J. Pharmacol. 122: 1061-1066. PMID: 9401770
4. Takahashi, A., et al. 1999. Circ. Res. 84: 543-550. PMID: 10082476
5. Spiecker, M., et al. 2002. Mol. Pharmacol. 62: 856-863. PMID: 12237332
6. Namazi, M.R. and Soma, J. 2005. Med. Hypotheses. 64: 1135-1137. PMID: 15823702

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), water (<1 mg/ml), and ethanol (<1 mg/ml).
Storage :
Store at room temperature
Melting Point :
166.2-168.2 °C (lit.)
Boiling Point :
585.55 °C at 760 mmHg
Density :
1.30 g/cm3
Refractive Index :
n20D 1.65
IC50 :
prostaglandin D2: IC50 = 0.1 mM; prostaglandin E2: IC50 = ~1-20 µM; thromboxane B2: IC50 = ~10-50 µM; TGF-β1: IC50 = ~100-200 µM; interleukin-8: IC50 = ~100 µM; Hematopoietic prostaglandin D synthase: IC50 = 1.16 µM (human)
pK Values :
pKa: 3.45
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DG8731000
PubChem CID :
5527
Merck Index :
14: 9570
MDL Number :
MFCD00864787
SMILES :
COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC

Download SDS (MSDS)

Certificate of Analysis

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Citations 1 to 1 of 1 total

PMID: # 23934019
2013. Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. J. Assist. Reprod. Genet.. 30: 1279-88.

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Rated 5 out of 5 by from Abdelaziz RR; et al Abdelaziz RR; et al. (PubMed ID: 26164743)determined that Tranilast increased hepatic functions in hepatic encephalopathy induced rats. -SCBT Publication Review
Date published: 2015-02-04
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