Tobramycin An aminoglycoside antibiotic

Tobramycin (CAS 32986-56-4)

Tobramycin | CAS 32986-56-4 is rated 4.0 out of 5 by 1.
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Synonym: Deoxykanamycin B; Distobram; Gernebcin
Application: An aminoglycoside antibiotic
CAS Number: 32986-56-4
Purity: ≥98%
Molecular Weight: 467.5
Molecular Formula: C18H37N5O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tobramycin is an aminoglycoside antibiotic with similar structure to the kanamycins and gentamycins. It is useful for respiratory infection and cystic fibrosis research.


References

Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use: R. N. Brogden, et al.; Drugs 12, 166 (1976), Review Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis: S.M. Cheer, et al.; Drugs 63, 2501 (2003), Review Tobramycin solution for inhalation in cystic fibrosis patients: a review of the literature: J.K. Hagerman, et al.; Expert Opin. Pharmacother. 8, 467 (2007), Review

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces tenebarius
Solubility :
Soluble in water (94 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), DMSO (<1 mg/ml at 25° C), methanol, and PBS (pH 7.2) (~10 mg/ml).
Storage :
Store at 4° C
Melting Point :
178° C (lit.)
Boiling Point :
~775.4° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
Optical Activity :
α20/D 143°±5°, c = 4 in water
IC50 :
Salmonella typhimurium: EC5050 = 1 ug/ml (Salmonella enterica subsp. enterica serovar Typhimurium)
pK Values :
pKa: 13.07 (Predicted), pKb: 9.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
WK2100000
PubChem CID :
36294
Merck Index :
14: 9490
MDL Number :
MFCD00077885
EC Number :
251-322-5
Beilstein Registry :
1357507
SMILES :
C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N

Download SDS (MSDS)

Certificate of Analysis

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Date published: 2015-04-20
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