Tobramycin is an aminoglycoside antibiotic with similar structure to the kanamycins and gentamycins. It is useful for respiratory infection and cystic fibrosis research.
Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use: R. N. Brogden, et al.; Drugs 12, 166 (1976), Review Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis: S.M. Cheer, et al.; Drugs 63, 2501 (2003), Review Tobramycin solution for inhalation in cystic fibrosis patients: a review of the literature: J.K. Hagerman, et al.; Expert Opin. Pharmacother. 8, 467 (2007), Review
Soluble in water (94 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), DMSO (<1 mg/ml at 25° C), methanol, and PBS (pH 7.2) (~10 mg/ml).
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