TIQ-AAn inhibitor of poly(ADP-ribose) polyerase-1 (PARP-1)

TIQ-A (CAS 420849-22-5)

TIQ-A | CAS 420849-22-5 is rated 5.0 out of 5 by 1.
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Synonym: Thieno[2,3-c]isoquinolin-5-one
Application: An inhibitor of poly(ADP-ribose) polyerase-1 (PARP-1)
CAS Number: 420849-22-5
Purity: ≥98%
Molecular Weight: 201.2
Molecular Formula: C11H7NOS
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

TIQ-A is a potent PARP-1 (poly(ADP-ribose) polymerase-1) inhibitor, IC50=450nM). Neuroprotective against oxygen-glucose deprivation injury in vitro in cultured murine cortical cells.


References

Chiarugi, A., et al.: J. Pharmacol. Exp. Ther., 305, 43 (2003), pellicciari, R., et al.: Farmaco., 58, 851 (2003) Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia: A. Chiarugi, et al.; J. Pharmacol. Exp. Ther. 305, 943 (2003) Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors: R. Pellicciari, et al.; Farmaco 58, 851 (2003)

Physical State :
Solid
Solubility :
Soluble in DMSO (16 mg/ml).
Storage :
Store at 4° C
Melting Point :
162.84° C (Predicted)
Boiling Point :
~282.17° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68
IC50 :
PARP-1 bovin recombinant : IC50 = 150 nM; cultured murine cortical cells: IC50 = 450 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9899130
MDL Number :
MFCD06407947
SMILES :
C1=CC=C2C(=C1)C3=C(NC2=O)SC=C3

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Kim H; et al Kim H; et al. (PubMed ID: 26183824) determined that TIQ-A inhibited PARP thus blocking E2-dependent growth of MCF-7 cells. -SCBT Publication Review
Date published: 2015-04-16
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