TipranavirA nonpeptidic protease inhibitor and antiviral agent

Tipranavir (CAS 174484-41-4)

Tipranavir | CAS 174484-41-4 is rated 5.0 out of 5 by 1.
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Synonym: N-[3-[(1R)-1-[(6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide
Application: A nonpeptidic protease inhibitor and antiviral agent
CAS Number: 174484-41-4
Molecular Weight: 602.66
Molecular Formula: C31H33F3N2O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tipranavir is a nonpeptidic HIV-1 (HIV) protease inhibitor (NPPI). Antiviral.


References

Poppe, S.M., et al.: Antimicrob. Agents Chemother., 41, 1058 (1997) McGregor, T.R., et al.: HIV Clin. Trials, 5, 371 (2004) Boffito, M., et al.: J. Clin. Pharmacol., 46, 130 (2006)

Physical State :
Solid
Solubility :
Soluble in methanol, Alcohol, and Propylene Glycol.
Storage :
Store at -20° C
Melting Point :
86-89° C
Boiling Point :
642.3-782.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +19.8º, c = 0.2 in methanol
IC50 :
Human immunodeficiency virus 1: IC50 = 1 nM; Human immunodeficiency virus 1: EC5050 = 22 nM; Human immunodeficiency virus type 1 protease: IC50 = 30 nM; Human immunodeficiency virus 2: IC50 = 145 nM; Human immunodeficiency virus 2: EC5050 = 0.3 µM
Ki Data :
Human immunodeficiency virus type 1 protease: Ki= 0.008 nM; Pepsin A: Ki= 2 µM (human); cathepsin E: Ki= 9 µM (human); cathepsin D: Ki= 15 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
65027
MDL Number :
MFCD00949098
SMILES :
CCC[C@]1(CC(=O)C(=C(O1)O)[C@H](CC)C2=CC(=CC=C2)NS(=O)(=O)C3=NC=C(C=C3)C(F)(F)F)CCC4=CC=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Mazza Mazza, F. et al. (PubMed 17169036) reported that the non-peptidic HIV protease inhibitor Tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line. -SCBT Publication Review
Date published: 2015-02-25
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