Tiotropium BromideAn antimuscarinic compound that prevents binding of acetylcholine

Tiotropium Bromide (CAS 136310-93-5)

Tiotropium Bromide | CAS 136310-93-5 is rated 5.0 out of 5 by 1.
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Application: An antimuscarinic compound that prevents binding of acetylcholine
CAS Number: 136310-93-5
Purity: ≥98%
Molecular Weight: 472.42
Molecular Formula: C19H22NO4S2•Br
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation.


References

Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994), Donohue, J. F., et al.: Chest, 122, 47 (2002), Profita, M., et al.: Allergy, 60, 1361 (2005), Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006),

Physical State :
Solid
Solubility :
Soluble in DMSO and Methanol
Storage :
Store at 4° C
Melting Point :
218-2200°C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60830
SMILES :
C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.[Br-]

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Certificate of Analysis

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Tiotropium Bromide  Product Citations

See how others have used Tiotropium Bromide. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27810937  Lai, YT. et al. 2016. J. Neurosci. 36: 12661-12676.

PMID: # 22954104  Deng, H. et al. 2012. Anal. Chem. 84: 8232-9.

Citations 1 to 2 of 2 total

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Date published: 2016-10-13
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Rated 5 out of 5 by from Anderson et al Anderson et al. (PubMed ID 26301488) found that patients given a beta-agonist treatment in conjunction with the long-acting muscarinic antagonist, tiotropium bromide, had a reduced likelihood of exacerbations requiring treatment and had improved lung function. -SCBT Publication Review
Date published: 2015-07-05
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