ThioFluor 623 A fluorescent thiol-reactive probe

ThioFluor 623 (CAS 1004324-99-5)

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Synonym: Fluorescent Thiol Probe
Application: A fluorescent thiol-reactive probe
CAS Number: 1004324-99-5
Purity: ≥98%
Molecular Weight: 678.67
Molecular Formula: C31H30N6O10S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold. The response is selective for thiols and occurs in aqueous media. In the absence of thiols, the probe is essentially non-fluorescent; thiols cause cleavage of the probe, making a fluorophore with an absorption maximum of 563 nm and emission at 623 nm. The fluorescence quantum yield of the cleaved product, generated in response to thiols, increases in more viscous media, suggesting ideal performance in biological systems and applicability to single-molecule or 2-photon sensing schemes. The thiofluor 623 is cell-permeable and reacts selectively with intracellular thiols.


References

1 Bouffard, J., Kim, Y., Swager, T.M., et al. A highly selective fluorescent probe for thiol bioimaging. Organic Lett 10(1) 37-40 (2008)

Physical State :
Solid
Solubility :
Soluble in ethanol, DMSO (~20 mg/ml), and DMF (~20 mg/ml).
Storage :
Store at -20° C
Fluoresence :
λex 563 nm, λem 623 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD18382093
SMILES :
COCCOCCOCCN(c1ccc(cc1)\\C=C/C1=C(CN)C(=C(CN)CN)OC1(C)C)S(=O)(=O)c1ccc(cc1[N](=O)O)[N](=O)O

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Certificate of Analysis

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