Thiocolchicine Thiocolchicine is an inhibitor of microtubules by specific binding to tubulin.

Thiocolchicine  (CAS 2730-71-4)

Thiocolchicine is rated 5.0 out of 5 by 1.
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Synonym: 10-Thio-colchicine
Application: A specific tubulin synthesis inhibitor and Topo I inhibitor
CAS Number: 2730-71-4
Molecular Weight: 415.5
Molecular Formula: C22H25NO5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Thiocolchicine sc-202838 100 mg $258.00
Thiocolchicine sc-202838A 5 mg $125.00

Thiocolchicine is an inhibitor of microtubules by specific binding to tubulin. Modulator of axonal cytoskeleton. Induces apoptosis. Topo I (topoisomerase I) inhibitor.


References

Association of thiocolchicine with tubulin: R.M. Chabin & S.B. Hastie; BBRC 161, 544 (1989) Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines: R. De Vincenzo, et al.; Anticancer Drug Des. 13, 19 (1998) Biological evaluation on different human cancer cell lines of novel colchicine analogs: R. De Vincenzo, et al.; Oncol. Res. 11, 145 (1999) Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve: P. Ferri, et al.; Exp. Toxicol. Pathol. 54, 211 (2002) Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors: G. Raspaglio, et al.; Biochem. Pharmacol. 69, 113 (2005)

Physical State :
Solid
Solubility :
Soluble in 100% ethanol, DMSO, methanol, and chloroform. Almost insoluble in water.
Storage :
Store at -20° C
Melting Point :
154-158° C
Boiling Point :
729.06° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Optical Activity :
α20/D -229.1°, c = 0.35 in chloroform
IC50 :
MDA-MB-231: IC50 = 0.6 nM (human); Human immunodeficiency virus 1: IC50 = 1.7 nM; L1210: IC50 = 8 nM (mouse); IGROV-1: IC50 = 12 nM (human); MCF7: IC50 = 0.4 µM (human)
Ki Data :
Tubulin alpha chain: Ki= 0.7 µM (pig)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
GH0878800
Transport :
UN 1544, Class 6.1, Packing group I
PubChem CID :
17648
EC Number :
220-346-8
SMILES :
CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Ho et al Ho et al. (PubMed ID 26355599) found that Thiocolchicine induced G2/M cell-cycle arrest and decreased mitochondrial membrane potential in human heptaocellular carcinomal cells by inducing endoplasmic reticular stress-mediated cell death. -SCBT Publication Review
Date published: 2015-02-10
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