Thiabendazole is a benzimidazole compound that acts as a fungicide and is reported to have aneugenic effects. Rat hepatocyte studies suggest that Thiabendazole mediates the induction of CYP1A1 and anuran Xenopus laevis studies demonstrate its ability to elevate the mRNA expression of hsp70 and IL-1β. Other studies indicate that Thiabendazole acts as a time dependent inhibitor of CYP1A2.
1. Lemaire, G., et al. 2004. Life Sci. 74: 2265-2278. PMID: 14987951 2. Thelingwani, R.S., et al. 2009. Drug Metab. Dispos. 37: 1286-1294. PMID: 19299526 3. Santovito, A., et al. 2010. Arch Toxicol. [Epub ahead of print]. PMID: 20938648 4. Martini, F., et al. 2010. Environ. Toxicol. Chem. 29: 2536-2543. PMID: 20886500
Soluble in ethanol (1 mg/ml), DMF (50 mg/ml), chlorinated hydrocarbons (slightly), DMSO (40 mg/ml), and water (<1 mg/ml).
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LiLi, W. et al. (PubMed 25645350) presented a method for the quantitative determination of trace Thiabendazole in apple juice utilizing dispersive liquid-liquid microextraction combined with fluorescence spectrophotometry. -SCBT Publication Review
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