Thiabendazole

Thiabendazole (CAS 148-79-8)

Thiabendazole | CAS 148-79-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-(4-Thiazolyl)-1H-benzimidazole; Tiabendazole; Mintezol; Mintesol; Omnizole; Tiabendazol; Lombristop; Thiabendazol; Thiabenzole
Application: A benzimidazole compound that acts as a fungicide and also against nematodes in Strongyloidiasis
CAS Number: 148-79-8
Purity: ≥98%
Molecular Weight: 201.25
Molecular Formula: C10H7N3S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Thiabendazole is a benzimidazole compound that acts as a fungicide and is reported to have aneugenic effects. Rat hepatocyte studies suggest that Thiabendazole mediates the induction of CYP1A1 and anuran Xenopus laevis studies demonstrate its ability to elevate the mRNA expression of hsp70 and IL-1β. Other studies indicate that Thiabendazole acts as a time dependent inhibitor of CYP1A2.


References

1. Lemaire, G., et al. 2004. Life Sci. 74: 2265-2278. PMID: 14987951
2. Thelingwani, R.S., et al. 2009. Drug Metab. Dispos. 37: 1286-1294. PMID: 19299526
3. Santovito, A., et al. 2010. Arch Toxicol. [Epub ahead of print]. PMID: 20938648
4. Martini, F., et al. 2010. Environ. Toxicol. Chem. 29: 2536-2543. PMID: 20886500

Physical State :
Solid
Solubility :
Soluble in ethanol (1 mg/ml), DMF (50 mg/ml), chlorinated hydrocarbons (slightly), DMSO (40 mg/ml), and water (<1 mg/ml).
Storage :
Store at 4° C
Melting Point :
301° C (lit.)
Boiling Point :
~446.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
Methionine aminopeptidase: IC50 = 472 nM (Escherichia coli K-12); CYP1A2: IC50 = 800 nM (human); Human immunodeficiency virus type 1 reverse transcriptase: IC50 = 14.6 µM; MetAP-2: IC50 = 44.7 µM (human); MetAP-1: IC50 = 47.8 µM (human)
Ki Data :
CYP2C9: Ki= 245 nM (human)
pK Values :
pKa: 10.53 (Predicted), pKb: 3.4 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DE0700000
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
5430
Merck Index :
14: 9298
MDL Number :
MFCD00005587
EC Number :
205-725-8
Beilstein Registry :
611403
SMILES :
C1=CC=C2C(=C1)NC(=N2)C3=CSC=N3

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Thiabendazole  Product Citations

See how others have used Thiabendazole. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25135636  Kidwell, MA. et al. 2014. J. Biol. Chem. 289: 28352-62.

PMID: # 23667708  Lee, YJ. et al. 2013. PLoS ONE. 8: e64337.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Li Li, W. et al. (PubMed 25645350) presented a method for the quantitative determination of trace Thiabendazole in apple juice utilizing dispersive liquid-liquid microextraction combined with fluorescence spectrophotometry. -SCBT Publication Review
Date published: 2015-07-13
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