Thiabendazole is a benzimidazole compound that acts as a fungicide and is reported to have aneugenic effects. Rat hepatocyte studies suggest that Thiabendazole mediates the induction of CYP1A1 and anuran Xenopus laevis studies demonstrate its ability to elevate the mRNA expression of hsp70 and IL-1β. Other studies indicate that Thiabendazole acts as a time dependent inhibitor of CYP1A2.
1. Lemaire, G., et al. 2004. Life Sci. 74: 2265-2278. PMID: 14987951 2. Thelingwani, R.S., et al. 2009. Drug Metab. Dispos. 37: 1286-1294. PMID: 19299526 3. Santovito, A., et al. 2010. Arch Toxicol. [Epub ahead of print]. PMID: 20938648 4. Martini, F., et al. 2010. Environ. Toxicol. Chem. 29: 2536-2543. PMID: 20886500
Soluble in ethanol (1 mg/ml), DMF (50 mg/ml), chlorinated hydrocarbons (slightly), DMSO (40 mg/ml), and water (<1 mg/ml).
PMID: # 25135636 Kidwell, MA. et al. 2014. Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing. J. Biol. Chem.. 289: 28352-62.
PMID: # 23667708 Lee, YJ. et al. 2013. The small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiae. PLoS ONE. 8: e64337.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
LiLi, W. et al. (PubMed 25645350) presented a method for the quantitative determination of trace Thiabendazole in apple juice utilizing dispersive liquid-liquid microextraction combined with fluorescence spectrophotometry. -SCBT Publication Review
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Why create an account?
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.