Theobromine A weak phosphodiesterase inhibitor and adenosine receptor blocker

Theobromine (CAS 83-67-0)

Theobromine | CAS 83-67-0 is rated 5.0 out of 5 by 1.
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Synonym: 3,7-Dimethylxanthine; Diurobromine; Santheose
Application: A weak phosphodiesterase inhibitor and adenosine receptor blocker
CAS Number: 83-67-0
Purity: ≥98%
Molecular Weight: 180.16
Molecular Formula: C7H8N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Theobromine is a weak PDE (phosphodiesterase) inhibitor and Adenosine A Receptor (adenosine receptor) blocker as well as a diuretic and smooth-muscle relaxant.


References

Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines: J.W. Daly, et al.; Cell Mol. Neurobiol. 3, 69 (1983) Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 0.5M sodium hydroxide (50 mg/ml), ethanol (<1 mg/ml at 25° C), water (<1 mg/ml at 25° C), DMSO (<1 mg/ml at 25° C), and methanol (hot).
Storage :
Store at room temperature
Melting Point :
357° C
Boiling Point :
483.47° C (Predicted)
Density :
1.50 g/cm3
Refractive Index :
n20D 1.74 (Predicted)
Ki Data :
Adenosine A1 receptor: Ki= 105 µM (rat); Adenosine A2 receptor: Ki= 250 µM (rat)
pK Values :
pKa: 9.9, pKb: 0.41 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
XH2275000
PubChem CID :
5429
Merck Index :
14: 9282
MDL Number :
MFCD00022830
EC Number :
201-494-2
Beilstein Registry :
16464
SMILES :
CN1C=NC2=C1C(=O)NC(=O)N2C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Jang et al Jang et al. (PubMed ID 26085110) found that theobromine blocked 3T3-L1 cell differentiation during adipogensis by regulating the expression of PPAR and C/EBP through the AMPK and ERK/JNK signaling pathways. -SCBT Publication Review
Date published: 2015-01-08
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