TGF-beta RI Kinase Inhibitor III An inhibitor of activin receptor-like kinase 4

TGF-β RI Kinase Inhibitor III (CAS 356559-13-2)

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Application: An inhibitor of activin receptor-like kinase 4
CAS Number: 356559-13-2
Purity: ≥97%
Molecular Weight: 371.9
Molecular Formula: C20H21N3O2 HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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TGF-β RI Kinase Inhibitor III is a cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of ACTR-IB (activin receptor-like kinase 4, IC50 = 129 nM), TGF β RI (activin receptor-like kinase 5, IC50 = 47 nM), and ACTR-IC (activin receptor-like kinase 7). TGF-β RI Kinase Inhibitor III inhibits p38 MAPKα only at much higher concentrations IC50 = 10.6 βM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.


References

Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816. DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml), and water (3 mg/ml).
Storage :
Store at 4° C
Boiling Point :
532.7° C at 760 mmHg (Predicted)
IC50 :
Activin receptor-like kinase 4: IC50 = 129 nM; Activin receptor-like kinase 5: IC50 = 47 nM; p38 MAPKα : IC50 = 10.6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16079009
SMILES :
Cl.Cc1cccc(n1)c1nc([nH]c1c1ccc2OCOc2c1)C(C)(C)C

Download SDS (MSDS)

Certificate of Analysis

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