Tetracycline hydrochloride An antiobiotic that inhibits protein synthesis in bacteria

Tetracycline hydrochloride (CAS 64-75-5)

Tetracycline hydrochloride | CAS 64-75-5 is rated 5.0 out of 5 by 1.
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Synonym: 2-naphthacenecarboxamid
Application: An antiobiotic that inhibits protein synthesis in bacteria
CAS Number: 64-75-5
Purity: ≥97%
Molecular Weight: 480.90
Molecular Formula: C22H24N2O8•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tetracycline Hydrochloride belongs to a family of broad-spectrum antibiotics that inhibit protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to the bacterial ribosome and has been used in a variety of root canal studies. In tick-borne encephalitis virus (TBEV) studies, tetracycline hydrochloride increased the concentrations of sIL-6R, IL-1RA, sTNFR1 and decreased the levels of TNF-α. Studies show that tetracycline can induce cold shock response and enhance expression of P450 proteins.


References

1. Chopra, I., et al. 1978. Microbiol. Rev. 42: 707-724. PMID: 739968
2. Kusano, K., et al. 1999. Arch. Biochem. Biophys. 367: 129-136. PMID: 10375408
3. Guan, J., et al. 2002. Zhonghua Bing Li Xue Za Zhi. 31: 135-139. PMID: 12419161
4. Atrasheuskaya, A.V., et al. 2003. Clin. Exp. Immunol. 131: 148-154. PMID: 12519399
5. Wu, Y. and Fassihi, R. 2005. Int J Pharm. 290: 1-13. PMID: 15664125

Usage :
Use at a concentration of 15 μg/ml
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml), DMSO, methanol, 0.1 N HCl (10 mg/ml), and ethanol. Insoluble in ether, and hydrocarbons.
Storage :
Store at -20° C
Melting Point :
220-223° C
Boiling Point :
799.4° C at 760 mmHg (Predicted)
Optical Activity :
α20/D -253°, c = 0.5 in 0.1mol/L HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
QI9100000
PubChem CID :
54704426
Merck Index :
14: 9196
MDL Number :
MFCD00078142
EC Number :
200-593-8
Beilstein Registry :
3844873
SMILES :
C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl

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Certificate of Analysis

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Tetracycline hydrochloride  Product Citations

See how others have used Tetracycline hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 16935844  Jia, D. et al. 2006. Endocrinology. 147(12): 5592-5599.

PMID: # 15940628  Cai, X. et al. 2005. Gastroenterology. 128: 1937-1952.

PMID: # 12925766  Honda, R. et al. 2003. Mol. Biol. Cell. 14: 3325-3341.

PMID: # 11956241  Weinstein, RS. et al. 2002. J. Clin. Invest. 109: 1041-1048.

PMID: # 10676627  Lloyd, DR. et al. 2000. Cancer Res. 60: 517-521.

PMID: # 10748054  Poe, J.C. et al. 2000. J. Biol. Chem. 275: 17420-17427.

PMID: # 9575187  Guo, Q. et al. 1998. J. Biol. Chem. 273: 12341-12351.

PMID: # 9418885  Shapiro, GI. et al. 1998. Mol. Cell. Biol. 18: 378-387.

PMID: # 9325318  Blain, SW. et al. 1997. J. Biol. Chem. 272: 25863-25872.

PMID: # 8999836  Hess, JA. et al. 1997. J. Biol. Chem. 272: 1615-1620.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Jia Jia, et. al. (PubMed ID 16935844) treated mice with tetracycline HCl, an antibiotic, 6 days and 2 days prior to sacrifice. -SCBT Publication Review
Date published: 2015-01-04
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