Tetracycline A compound that has been shown to induce apoptosis in various cells

Tetracycline (CAS 60-54-8)

Tetracycline | CAS 60-54-8 is rated 5.0 out of 5 by 1.
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Synonym: Deschlorobiomycin; Ambramycin; Liquamycin
Application: A compound that has been shown to induce apoptosis in various cells
CAS Number: 60-54-8
Molecular Weight: 444.43
Molecular Formula: C22H24N2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tetracycline is used for treatment of chronic inflammatory cells. Tetracycline derivatives induce apoptosis in osteoclasts, Jurkat T lymphocyte cells and in cultured monocytes and macrophages.


References

Bettany JT, Peet NM, Wolowacz RG et al. Bone. 27:75-80 (2000). Liu J, Kuszynski CA, Baxter BT. Biochem Biophys Res Commun. 260:562-7 (1999). Bettany JT, Wolowacz RG. Adv dent Res. 12: 136-43 (1998).

Formulation :
≥975 u/mg
Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (1.7 mg/ml), and methanol (> 20 mg/ml).
Storage :
Store at 4° C
Melting Point :
170-175° C (lit.)(dec.)
Boiling Point :
~790.62° C at 760 mmHg (Predicted)
Density :
~1.64 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
Optical Activity :
α20/D -230°±5°, c = 1 in methanol; α20/D -250°, c = 0.5 in 0.1 N HCl
IC50 :
Pseudomonas aeruginosa: IC50 = 135 nM; Staphylococcus epidermidis: IC50 = 180 nM; Escherichia coli: IC50 = 202.51 nM; Staphylococcus aureus: IC50 = 270.01 nM; Plasmodium falciparum: IC50 = 323.9 nM
Ki Data :
P2Y12: Ki= >10 µM (human)
pK Values :
pKa: 4.5 (Predicted), pKb: 11.02 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QI8750000
PubChem CID :
54675776
Merck Index :
14: 9196
MDL Number :
MFCD00151232
EC Number :
200-481-9
Beilstein Registry :
2230417
SMILES :
C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

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Certificate of Analysis

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Tetracycline  Product Citations

See how others have used Tetracycline. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21542139  Wang, WH. et al. 2011. Anat Rec (Hoboken). 294: 1025-1034.

Citations 1 to 1 of 1 total

what is this drug solvent? and how dissolve the solvent (%)?

Asked by: ToTo
Thank you for your question. This drug is soluble in methanol, giving a completely clear solution at up to 30 mg/ml. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-15
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Rated 5 out of 5 by from Choi S; et al Choi S; et al. (PubMed ID: 26386640) identified that Tetracycline, a broad spectrum antibiotic, has an increased bactericidal effect when used in combination with photodynamic therapy (PDT). -SCBT Publication Review
Date published: 2015-04-14
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