Terreic acid is a metabolite that displays antibiotic properties. Terreic Acid has been found to covalently inhibit UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA), a bacterial cell wall biosynthetic enzyme. This compound has also been found to inhibit the catalytic activity of BTK (Bruton's tyrosine kinase) and the interaction of Btk with protein kinase C beta type (PKCβII) without affecting the activity of PKC. Terreic Acid is useful to study BTK's role in cellular signaling.
1. Lusková, P., et al. 2004. Curr. Pharm. Des. 10: 1727-1737. PMID: 15180535 2. Han, H., et al. 2010. Biochemistry. 49: 4276-4782. PMID: 20392080 3. Kawakami, Y., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 2227-2232. PMID: 10051623
Soluble in water (3 mg/ml with warming and stirring).
Store at -20° C
333.56° C at 760 mmHg
interaction between PKCbII and BTK : IC50 = ~ 30 mM; BTK catalytic activity: IC50 = 10 µM; interaction between the BTK-PH and PKC: IC50 = ~ 100 µM (human mast cell lysates); BTK basal and activation levels: IC50 = 3 µM; autophosphorylating activity of PKCβI: IC50 = ~ 8 µM; TNF-α: IC50 = ~ 3 µM (FcεRI-stimulated mast cells); activation of JNK1: IC50 = ~ 10 µM (FcεRI-stimulated mast cells); DNA synthesis: IC50 = ~ 1.5 µM (activated spleen cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Date published: 2016-11-03
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Kawakami et alKawakami et al. (PubMed ID 10051623) found that terreic acid inhibited the enzymatic activity of Bruton's tyrosine kinase in mast cells and cell-free assays. -SCBT Publication Review
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