Tetramethyl Nordihydroguaiaretic Acid is a synthetic derivative of NDGA and a non-selective LO (lipoxygenase) inhibitor. Tetramethyl Nordihydroguaiaretic Acid inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter (a gene essential for HSV replication).
1 Hwu, J.R., Tseng, W.N., Gnabre, J., et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem 41 2994-3000 (1998). 2 Chen, H., Teng, L., Li, J., et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem 41 3001-3007 (1998). 3 Chang, C., Heller, J.D., Kuo, J., et al. Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression. Proc Natl Acad Sci USA 101(36) 13239-13244 (2004). 4 Park, R., Chang, C., Liang, Y., et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res 11(12) 4601-4609 (2005). 5 Lambert, J.D., Meyers, R.O., Timmermann, B.N., et al. Tetra-O-methylnordihydroguaiaretic acid inhibits melanoma in vivo. Cancer Lett 171 47-56 (2001).
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