Tenuazonic acid

Tenuazonic acid (CAS 610-88-8)

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Application: A mycotoxin natural product with antibacterial and antineoplastic effects
CAS Number: 610-88-8
Molecular Weight: 197.3
Molecular Formula: C10H15NO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tenuazonic acid is an antineoplastic, mycotoxic compound extracted from Alternaria alternata exhibiting antiviral, antibacterial and antitumor activity. Tenuazonic acid inhibits protein synthesis by suppression at the ribosome. Tenuazonic acid was shown to inhibit TPA induced ornithine decarboxylase (ODC) activity in a mouse model, and in turn suppressed mouse skin tumor promotion. A natural phytotoxic agent that has been shown to be a new type of Photosystem II inhibitor.


References

1. Cole, M. and Rolinson, G.N. 1972. Appl Microbiol. 24: 660-662. PMID: 4628800
2. Gatenbeck, S., et al. 1973. Antimicrob. Agents Chemother. 3: 308-309. PMID: 4790594
3. Antony, M., et al. 1991. Cancer Lett. 61: 21-25. PMID: 1764695
4. Antony, M., et al. 2002. Teratog., Carcinog. Mutagen. 22: 309-314. PMID: 12111715
5. Chen, S., et al. 2007. Biochim. Biophys. Acta. 1767: 306-318. PMID: 17379181

Physical State :
Solid
Derived From :
Alternaria sp.
Solubility :
Soluble in DMSO, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
152.55° C (Predicted)
Boiling Point :
401.07° C at 760 mmHg (Predicted)
Density :
1.18 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
pK Values :
pKa: 4.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UY7425000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
11893
Merck Index :
14: 9149
MDL Number :
MFCD00055596
SMILES :
CCC(C)C1C(=O)C(=C(N1)O)C(=O)C

Download SDS (MSDS)

Certificate of Analysis

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