TC 14012 An antagonist of CXCR4 and agonist of CXCR7

TC 14012 (CAS 368874-34-4)

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Synonym: L- arginyl- L- arginyl- 3- (2- naphthalenyl)- L- alanyl- L- cysteinyl- L- tyrosyl- N5- (aminocarbonyl)- L- ornithyl- L- lysyl- N5- (aminocarbonyl)- D- ornithyl- L- prolyl- L- tyrosyl- L- arginyl- N5- (aminocarbonyl)- L- ornithyl- L- cysteinyl- cyclic (4→13)- disulfide- L-
Application: An antagonist of CXCR4 and agonist of CXCR7
CAS Number: 368874-34-4
Molecular Weight: 2066.43
Molecular Formula: C90H140N34O19S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Physical State :
Solid
Sequence :
RRACYXKXPYRXCR (Modifications: Disulfide bridge between 4 - 13, Arg-14 = C-terminal amide, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline)
Solubility :
Soluble in water (~2 mg/ml), and acetonitrile (~2 mg/ml).
Storage :
Store at -20° C
IC50 :
CXCR4-mediated HIV infection: IC50 = 19.3 nM; CXCR-7: EC5050 = 350 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD19690961
SMILES :
c1ccc2cc(ccc2c1)C[C@@H](C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)Cc5ccc(cc5)O)CCCNC(=O)N)CCCCN)CCCNC(=O)N)Cc6ccc(cc6)O)CCCNC(=N)N)CCCNC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N

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Certificate of Analysis

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