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MelchersMelchers, MJ. et al. (PubMed 25824214) investigated the plasma and epithelial lining fluid pharmacokinetics (PK) of ceftolozane and tazobactam alone and in combination in mice. Thigh-infected neutropenic CD-1 mice were injected intraperitoneally with a single 0.1-ml dose containing ceftolozane, tazobactam, or both compounds. Ceftolozane was applied in 2-fold-increasing doses of 4 mg/kg of body weight to 64 mg/kg alone or in combination. There were no significant differences in the ceftolozane and tazobactam PK alone versus combined, indicating no PK interaction. The PKs were linear and dose proportional for both compounds and showed a good penetration in the epithelial lining fluid. -SCBT Publication Review
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