Tazobactam sodium A β-lactamase inhibitor and antibacterial agent

Tazobactam sodium (CAS 89785-84-2)

Tazobactam sodium | CAS 89785-84-2 is rated 5.0 out of 5 by 1.
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Synonym: YTR-830
Application: A β-lactamase inhibitor and antibacterial agent
CAS Number: 89785-84-2
Purity: ≥98%
Molecular Weight: 322.274
Molecular Formula: C10H11N4NaO5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tazobactam sodium is a LACTB (β-lactamase) inhibitor and antibacterial.


References

1. Bryson, H.M. and Brogden, R.N. 1994. Drugs. 47: 506-535. PMID: 7514977

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), and methanol.
Storage :
Store at room temperature
Melting Point :
140-147° C
Boiling Point :
707.1° C
Refractive Index :
n20D ~1.82 (Predicted)
IC50 :
β-lactamase TEM: IC50 = 25 nM (escherichia coli); β-lactamase: IC50 = 290 nM (staphylococcus aureus)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XI0191500
PubChem CID :
23663400
MDL Number :
MFCD00917472
SMILES :
C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])CN3C=CN=N3.[Na+]

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Certificate of Analysis

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Tazobactam sodium  Product Citations

See how others have used Tazobactam sodium. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26119190  2015. Int. J. Food Microbiol. 210: 131-5.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The chemical, sc-205853, is provided as a white to off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-11
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Rated 5 out of 5 by from Melchers Melchers, MJ. et al. (PubMed 25824214) investigated the plasma and epithelial lining fluid pharmacokinetics (PK) of ceftolozane and tazobactam alone and in combination in mice. Thigh-infected neutropenic CD-1 mice were injected intraperitoneally with a single 0.1-ml dose containing ceftolozane, tazobactam, or both compounds. Ceftolozane was applied in 2-fold-increasing doses of 4 mg/kg of body weight to 64 mg/kg alone or in combination. There were no significant differences in the ceftolozane and tazobactam PK alone versus combined, indicating no PK interaction. The PKs were linear and dose proportional for both compounds and showed a good penetration in the epithelial lining fluid. -SCBT Publication Review
Date published: 2015-03-27
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