Tazobactam, Free acid A β-lactamase inhibitor

Tazobactam, Free acid (CAS 89786-04-9)

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Application: A β-lactamase inhibitor
CAS Number: 89786-04-9
Molecular Weight: 300.29
Molecular Formula: C10H12N4O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tazobactam, free acid, is a β-lactamase (LACTB) inhibitor with antibacterial activity.


References

1. Bryson, H M., et al., 1994. Piperacillin/tazobactam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential. Drugs. 47(3): 506-35. PMID: 7514977

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at room temperature
Melting Point :
170-178° C
Boiling Point :
~707.1° C at 760 mmHg (Predicted)
Density :
~1.9 g/cm3 (Predicted)
Refractive Index :
n20D 1.82 (Predicted)
IC50 :
β-lactamase: IC50 = 6 ng/mL (Proteus mirabilis); β-lactamase TEM: IC50 = 6 ng/mL (Escherichia coli); β-lactamase BRO-1: IC50 = 10 ng/mL (Moraxella catarrhalis); β-lactamase: IC50 = 32 ng/mL (Klebsiella oxytoca); β-lactamase SHV-1: IC50 = 40 ng/mL (Escherichia coli)
Ki Data :
β-lactamase TEM-1: Ki= 30 nM; Escherichia coli MC4100 β-Lactamase CMY-2: Ki= 800 nM; β-lactamase OXA-14 : Ki= 30 µM; β-lactamase OXA-17: Ki= 40 µM; Klebsiella pneumoniae 1534 β-lactamase KPC-2 T237S mutant : Ki= 53 µM
pK Values :
pKa: 2.33 (Predicted), pKb: 0.85 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
123630
Merck Index :
14: 9083
MDL Number :
MFCD00867002
Beilstein Registry :
4787943
SMILES :
CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3

Download SDS (MSDS)

Certificate of Analysis

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Tazobactam, Free acid  Product Citations

See how others have used Tazobactam, Free acid. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 7514977  Bryson, HM. et al. 1994. Drugs. 47: 506-535.

Citations 1 to 1 of 1 total
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