Tautomycin

Tautomycin (CAS 109946-35-2)

Tautomycin | CAS 109946-35-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_4, d_23, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200587, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 114ms
  • REVIEWS, PRODUCT
Application: A potent and specific PP1 and PP2 inhibitor
CAS Number: 109946-35-2
Purity: ≥85%
Molecular Weight: 766.95
Molecular Formula: C41H66O13
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Tautomycin is a potent and specific protein phosphatase inhibitor that functions as an antifungal antibiotic. Protein phosphatase-1 (Kiapp = 0.16 nM) (PP1) is more potently inhibited by tautomycin than protein phosphatase 2A (Kiapp = 0.4 nM) (PP2). Studies show that in the presence of tautomycin the expression levels of transferring receptor (TFR) increase and it also blocks PDBu-induced down regulation of CD4. Medullary thyroid cancer (MTC) cells treated with tautomycin and tautomycetin (sc-204321), also an antifungal antibiotic, showed suppressed levels of hormonal secretion, decreased neuroendocrine markers, and inhibition of growth through apoptosis. Both compounds, tautomycin and tautomycetin, can inhibit the growth of MTC cells by blocking glycogen synthase kinase-3β. Tautomycin can also activate the Raf-1 pathway, prevent neuroendocrine (NE) production, and decrease carcinoid cell development.


References

1. MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277: 137-140. PMID: 2176611
2. Hori, M., et al. 1991. FEBS Lett. 285: 145-148. PMID: 1648511
3. Kurisaki, T., et al. 1992. J. Antibiot. 45: 252-257. PMID: 1556018
4. Pinchot, S.N., et al. 2009. Am. J. Surg. 197: 313-319. PMID: 19245907
5. Adler, J.T., et al. 2009. Mol. Cancer Ther. 8: 914-920. PMID: 19372564
6. Ju, J., et al. 2009. Org. Lett. 11: 1639-1642. PMID: 19281218

Appearance :
Film
Physical State :
Solid
Derived From :
Streptomyces spiroverticillatus
Solubility :
Soluble in 100% ethanol, methanol, ethyl acetate, DMSO, acetone, water (slightly soluble), and chloroform.
Storage :
Store at -20° C
Boiling Point :
854.28° C at 760 mmHg (Predicted)
Density :
1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
IC50 :
Serine/threonine protein phosphatase PP1-gamma catalytic subunit: IC50 = 0.7 nM (human); Serine-threonine protein phosphatase 2A regulatory subunit: IC50 = 0.7 nM (Gallus gallus); Protein-tyrosine phosphatase 1B: IC50 = 0.67 nM (human); Serine/threonine protein phosphatase PP1-alpha catalytic subunit: IC50 = 0.7 nM (human)
pK Values :
pKa: 12.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WX1000000
Transport :
UN 3462, Class 6.1, Packing group II
PubChem CID :
440646
MDL Number :
MFCD00236438
SMILES :
C[C@@H]1CC[C@@]2(CC[C@@H]([C@@H](O2)[C@H](C)CC[C@@H]([C@H](C)C(=O)C[C@H]([C@H]([C@@H](C(C)C)OC(=O)C[C@H](C3=C(C(=O)OC3=O)C)O)OC)O)O)C)O[C@H]1CC[C@H](C)C(=O)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Tautomycin  Product Citations

See how others have used Tautomycin. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27142525  Guillonneau, M. et al. 2016. FASEB J. 30: 2899-914.

PMID: # 26392083  Gotoh, S. et al. 2015. Sci Rep. 5: 14076.

PMID: # 24618897  Williams, BC. et al. 2014. Elife. 3: e01695.

PMID: # 19245907  Pinchot, SN. et al. 2009. Am. J. Surg. 197: 313-319.

PMID: # 17360714  Guan, L. et al. 2007. J Biol Chem. 282: 14213-14225.

Citations 1 to 5 of 5 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 13ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Ju et al Ju et al. (PubMed ID 19281218) found that Tautomycin (TTM) induced cell death by inhibiting protein phosphatase. -SCBT Publication Review
Date published: 2015-03-09
  • y_2019, m_4, d_23, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200587, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 259ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.