Taurolidine Taurolidine is antibiotic with broad activity, as well demonstrated antitumor, antiangiogenic, and antiendotoxin activity; also found to induce apoptosis in tumor cell models.

Taurolidine  (CAS 19388-87-5)

Taurolidine is rated 5.0 out of 5 by 1.
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| See 1 Citations
Synonym: Taurolin; Tauroline
Application: An antibiotic
CAS Number: 19388-87-5
Purity: ≥98%
Molecular Weight: 284.36
Molecular Formula: C7H16N4O4S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Taurolidine sc-202827 10 mg $45.00
Taurolidine sc-202827A 50 mg $165.00

Taurolidine is a broad spectrum antibiotic that was derived from the aminosulfoacid Taurine (sc-202354). Shown to be effective against aerobic, anaerobic, gram-negative and gram-positive bacteria as well as fungi and mycobacterium. Found to exhibit antitumor activity with low toxicity, antiangiogenic effects, antiendotoxin activity, and to induce apoptosis of tumor cells; thereby decreasing proliferation of the tumor cells (both in vitro and in vivo). Has been used in studies of alternative chemotherapeutics, and is shown to work synergistically with rhTRAIL (sc-4547) doubling the effects of Taurolidine alone. The synergistic response of Taurolidine and TRAIL may outline a new therapeutic strategy in oncology therapy.


References

1. Watson, R.W., et al. 1995. J. Leukoc. Biol. 58: 299-306. PMID: 7665985
2. McCourt, M., et al. 2000. Ann. Surg. Oncol. 7: 685-691. PMID: 11034247
3. Calabresi, P., et al. 2001. Cancer Res. 61: 6816-6821. PMID: 11559556
4. Stendel, R., et al. 2009. Autophagy. 5: 194-210. PMID: 19066471
5. Jacobi, C.A., et al. 2005. Anticancer Drugs. 16: 917-921. PMID: 16162968
6. Bradshaw, J.H., et al. 2008. J. Pediatr. Gastroenterol. Nutr. 47: 179-186. PMID: 18664870
7. Daigeler, A., et al. 2008. Int. J. Oncol. 32: 1205-1220. PMID: 18497982
8. Chromik, A.M., et al. 2007. J Invest Surg. 20: 339-348. PMID: 18097875

Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in DMSO (>20 mg/ml), and water.
Storage :
Store at -20° C
Melting Point :
189.55° C (Predicted)
Boiling Point :
471.21° C at 760 mmHg (Predicted)
Density :
1.47 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
pK Values :
pKa: 11.16 (Predicted), pKb: 2.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
29566
Merck Index :
14: 9076
MDL Number :
MFCD00865076
EC Number :
243-016-5
SMILES :
C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2

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Certificate of Analysis

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Citations 1 to 1 of 1 total

PMID: # 25234575
Rimann, M. et al. 2014. An in vitro osteosarcoma 3D microtissue model for drug development. Journal of biotechnology. 189: 129-35.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from A large increase in ATF A large increase in ATF-3 protein expression was observed by WB in HT-1080 cells after treatment with Taurolidine. -SCBT QC
Date published: 2015-04-27
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