Taurocholic Acid A choleretic steroid useful for the quantification of conjugated bile acids

Taurocholic Acid (CAS 81-24-3)

Taurocholic Acid | CAS 81-24-3 is rated 5.0 out of 5 by 1.
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Synonym: Cholaic Acid
Application: A choleretic steroid useful for the quantification of conjugated bile acids
CAS Number: 81-24-3
Molecular Weight: 515.70
Molecular Formula: C26H45NO7S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Taurocholic Acid is a choleretic steroid which has been used for the quantification of conjugated bile acids in dried blood spots using electrospray ionization-mass spectrometry. Additionally, its sodium salt can act as a lipase accelerator.


References

Mills, K.A., et al.: Pedatric Res., 43, 3 (1998).

Appearance :
Crystalline or powder
Physical State :
Solid
Solubility :
Soluble in water, hot alcohol, ethyl acetate (slightly), and ether.
Storage :
Store at 4° C
Melting Point :
125° C
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Optical Activity :
α18/D +38.8º, c = 0.002 in alcohol
IC50 :
Plasmodium falciparum: IC50 = 3.16 µM; Bile acid transporter: IC50 = 5.3 µM (human); Bile acid transporter: IC50 = 6.0 µM (rat); Multidrug resistance associated protein: IC50 = 40.0 µM (human); Multidrug resistance-associated protein 4: IC50 = 250 µM (human)
Ki Data :
Solute carrier organic anion transporter family member 1A1: Ki= 10.8 µM (rat); Solute carrier organic anion transporter family member 1A4: Ki= 39.4 µM (rat); Ileal bile acid transporter: Ki= 41.5 µM (human); Solute carrier organic anion transporter family member 1C1: Ki= 109 µM (rat); Solute carrier organic anion transporter family member 1A3: Ki= 183 µM (rat)
pK Values :
pKa: 1.42 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6675
Merck Index :
14: 9075
MDL Number :
MFCD00053458
SMILES :
C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C

Download SDS (MSDS)

Certificate of Analysis

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Taurocholic Acid  Product Citations

See how others have used Taurocholic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28793934  Caparrós-Martín, JA. et al. 2017. Microbiome. 5: 95.

Citations 1 to 1 of 1 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. The compound, sc-220189, is soluble in water, hot alcohol, ether, and slightly soluble in ethyl acetate. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-24
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Rated 5 out of 5 by from Various publications cite the use of Taurocholic Various publications cite the use of Taurocholic Acid, a choleretic steroid, for the quantification of conjugated bile acids in dried blood spots using electrospray ionization-mass spectrometry. -SCBT Publication Review
Date published: 2015-02-22
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