Swainsonine A potent α-mannosidase inhibitor and immunomodulator

Swainsonine (CAS 72741-87-8)

Swainsonine | CAS 72741-87-8 is rated 5.0 out of 5 by 1.
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Synonym: Tridolgosir
Application: A potent α-mannosidase inhibitor and immunomodulator
CAS Number: 72741-87-8
Purity: ≥98%
Molecular Weight: 173.21
Molecular Formula: C8H15NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Swainsonine, an indolizidine alkaloid, has been shown to inhibit the breakdown of glycoprotein by rat liver lysosomes and also suppress MAN2A1 (Golgi mannosidase II). This compound has been reported to be a potent antiproliferative and immunomodulatory agent via stimulation of lymphocyte proliferation. Additionally, Swainsonine displays the ability to inhibit MAN2B1 (lysosomal α-mannosidase) and MAN2C1. Mechanistic studies suggest that this agent can alter carbohydrate processing of β-galactosidase and β-glucuronidase.


References

1. Winkler, J.R., et al. 1984. J. Biol. Chem. 259: 15369-15372. PMID: 6210288
2. Granato, D.A., et al. 1987. Mol. Immunol. 24: 849-855. PMID: 3116410
3. White, S.L., et al. 1988. Biochem. Biophys. Res. Commun. 150: 615-625. PMID: 3124836
4. Humphries, M.J., et al. 1988. Cancer Res. 48: 1410-1415. PMID: 3125963
5. Tropea, J.E., et al. 1988. J. Biol. Chem. 263: 4309-4317. PMID: 3126186

Physical State :
Solid
Solubility :
Soluble in 100% ethanol, DMSO, methanol, water (10 mg/ml), DMF (~10 mg/ml), and PBS (pH=7.2) (0.25 mg/ml).
Storage :
Store at -20° C
Melting Point :
102.62° C (Predicted)
Boiling Point :
~353.3° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.61
IC50 :
lysosomal α-mannosidase and Golgi α-mannosidase II : IC50 = 0.2 µM; golgi alpha-mannosidase 2: IC50 = 0.04 µM (drosophila ); jack bean alpha-mannosidase: IC50 = 0.04 µM
Ki Data :
golgi alpha-mannosidase 2: Ki= 20 nM (drosophila ); melanogaster GM2b: Ki= 3 nM (drosophila )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NM2408666
PubChem CID :
51683
MDL Number :
MFCD00017554
EC Number :
615-797-6
Beilstein Registry :
4175740
SMILES :
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O

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Certificate of Analysis

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Swainsonine  Product Citations

See how others have used Swainsonine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 18655794  Chakraborty, D. et al. 2008. Life Sci. 83: 260-263.

PMID: # 6786280  Dorling, PR. et al. 1980. Biochem. J. 191: 649-651.

Citations 1 to 2 of 2 total

Hi, we hope to order this drug in larger amount. Is there a quote available for ~30mg? Thanks.

Asked by: Stan_DFCI
Thank you for your question. Please contact our Technical Service Department to inquire about special pricing and bulk orders for this chemical. This is for research use only, and not for diagnostic or therapeutic use. Please call us toll-free at (800) 457-3801 option 2, or e-mail <specialorders@scbt.com>.
Answered by: Technical Support
Date published: 2017-08-23
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Rated 5 out of 5 by from Chakraborty Chakraborty, et. al. (PubMed ID 18655794) found that Swainsonine reduced the tyrosinase activity in melanotic hybrid 95-H1 cells by 30 40% when treated with 1 g/ml for 2 days. Increases in migration rate of the tyrosinase protein in SDS-PAGE was also observed post treatment. -SCBT Publication Review
Date published: 2015-05-05
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