Suppressor of topoisomerase II inhibition. Reverses cell cycle arrest; bypass of checkpoint function. Has inherent fluorescence and a distinct advantage in identification of molecule targets; effective concentraion in the µM range.
Haggerty, S.J., et al., Small molecule modulation of the human chromatid decatenation checkpoint. Chem. Biol. 10, 1267-1279, (2003) Koeller, K.M., et al., Chemical genetic modifier screens; small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem. Biol. 10, 397-410, (2003)
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