Sulfathiazole sodium salt A competitive inhibitor of bacterial para-aminobenzoic acid (PABA)

Sulfathiazole sodium salt (CAS 144-74-1)

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Synonym: monosodium2-sulfanilamidothiazole
Application: A competitive inhibitor of bacterial para-aminobenzoic acid (PABA)
CAS Number: 144-74-1
Purity: ≥99%
Molecular Weight: 277.30
Molecular Formula: C9H8N3O2S2•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sulfathiazole sodium salt is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal's only source of available folate is from their diet. Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Appearance :
Powder
Physical State :
Solid
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
12285822
SMILES :
C1=CC(=CC=C1N)S(=O)(=O)[N-]C2=NC=CS2.[Na+]

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