Sulfasalazine is an antiinflammatory agent that inhibits GSH-H-transferase. Sulfasalazine largely inhibits NF-κB activation and induces apoptosis in T-lymphocytes. The compound also engages neutrophil apoptosis that can be abrogated by Tyr-K inhibitors, PKA inhibitors, or antioxidants. Sulfasalazine is shown to inhibit basic fibroblast growth factor-induced endothelial cell chemotaxis. Sulfasalazine is an inhibitor of TNFα and an activator of PPARγ.
Liptay, S., et al. 1999. Br. J. Pharmacol. 128, 1361. Volin, M.V., et al. 1999. Arthritis Rheum. 42, 1927. He, N.G., et al. 1998. Toxicol. Appl. Pharmacol. 152, 83. Akahoshi, T., et al. 1997. J. Leukoc. Biol. 62, 817. Awasthi, S., et al. 1994. Br. J. Cancer 70, 190.
Soluble in DMSO (100 mg/ml), and 1 M NH4OH (50 mg/ml).
Rated 5 out of
Sykes et alSykes et al. (PubMed ID 26395271) found that Sulfasalazine inhibition of IL-1 -induced cytokine production in amniocytes and monocytes could be used for the prevention of inflammation-induced preterm labor. -SCBT Publication Review
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