Sulfasalazine An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer

Sulfasalazine (CAS 599-79-1)

Sulfasalazine | CAS 599-79-1 is rated 5.0 out of 5 by 1.
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Synonym: 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid
Application: An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer
CAS Number: 599-79-1
Purity: ≥95%
Molecular Weight: 398.39
Molecular Formula: C18H14N4O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sulfasalazine is an antiinflammatory agent that inhibits GSH-H-transferase. Sulfasalazine largely inhibits NF-κB activation and induces apoptosis in T-lymphocytes. The compound also engages neutrophil apoptosis that can be abrogated by Tyr-K inhibitors, PKA inhibitors, or antioxidants. Sulfasalazine is shown to inhibit basic fibroblast growth factor-induced endothelial cell chemotaxis. Sulfasalazine is an inhibitor of TNFα and an activator of PPARγ.


References

Liptay, S., et al. 1999. Br. J. Pharmacol. 128, 1361. Volin, M.V., et al. 1999. Arthritis Rheum. 42, 1927. He, N.G., et al. 1998. Toxicol. Appl. Pharmacol. 152, 83. Akahoshi, T., et al. 1997. J. Leukoc. Biol. 62, 817. Awasthi, S., et al. 1994. Br. J. Cancer 70, 190.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), and 1 M NH4OH (50 mg/ml).
Storage :
Store at room temperature
Melting Point :
260-265° C (dec.)
Boiling Point :
689.35° C at 760 mmHg (Predicted)
Density :
1.50 g/cm3 at 25° C
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Glutathione-S-transferase: IC50 = 10 µM (HG9 cell line)
pK Values :
pKa: 2.88
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
VO6250000
PubChem CID :
5384001
Merck Index :
14: 8942
MDL Number :
MFCD00057363
EC Number :
209-974-3
Beilstein Registry :
356241
SMILES :
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)NN=C3C=CC(=O)C(=C3)C(=O)O

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Certificate of Analysis

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Sulfasalazine  Product Citations

See how others have used Sulfasalazine. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28630042  Koppula, P. et al. 2017. J. Biol. Chem.

PMID: # 26093909  Yco, LP. et al. 2015. BMC Cancer. 15: 477.

PMID: # 22481440  Kysenius, K. et al. 2012. Cellular and molecular life sciences : CMLS. 69: 1903-16.

Citations 1 to 3 of 3 total

Can this product be stored at -20oC after dissolving in DMSO?

Asked by: hawkeye11
Thank you for your question. Yes, this compound is stable at -20 degrees Celsius for up to 6 months. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-12-06
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Rated 5 out of 5 by from Sykes et al Sykes et al. (PubMed ID 26395271) found that Sulfasalazine inhibition of IL-1 -induced cytokine production in amniocytes and monocytes could be used for the prevention of inflammation-induced preterm labor. -SCBT Publication Review
Date published: 2015-01-17
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