Sulfaphenazole A specific inhibitor of CYP2C9

Sulfaphenazole (CAS 526-08-9)

Sulfaphenazole | CAS 526-08-9 is rated 4.5 out of 5 by 2.
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Synonym: 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Application: A specific inhibitor of CYP2C9
CAS Number: 526-08-9
Purity: ≥98%
Molecular Weight: 314.36
Molecular Formula: C15H14N4O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.


References

1. Schmidt, P., and Druery, J. Helv. Chim. Acta 41, 306, (1958)
2. Viswanathan, S. et al. 2003. J Am Coll Nutr. 22(6): 502-510. PMID: 14684755
3. Posadino, A.M. et al. 2015. Food Chem. Toxicol. 78 : 10-16. PMID: 25656643

Appearance :
Powder
Physical State :
Solid
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5335
SMILES :
C1=CC=C(C=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)N

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Sulfaphenazole  Product Citations

See how others have used Sulfaphenazole. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27841077  Sekiguchi, N. et al. 2017. Xenobiotica. 47: 1042-1051.

PMID: # 28969895  Luo, Y. et al. 2017. Cytotherapy.

PMID: # 28949811  Quinney, SK. et al. 2017. Fetal Pediatr Pathol. 36: 400-411.

PMID: # 26174047  Feng, R. et al. 2015. Scientific reports. 5: 12155.

PMID: # 25422175  Wang, W. et al. 2015. Chirality. 27: 170-6.

Citations 1 to 5 of 5 total
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Date published: 2015-04-20
Rated 5 out of 5 by from Posadino AM; et al Posadino AM; et al. (PubMed ID: 25656643) determined that Sulfaphenazole, cytochrome P450 (CYP) 2C9 inhibitor, prevented both mitochondrial membrane depolarization and oxidative stress. -SCBT Publication Review
Date published: 2015-04-20
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