Substance P is a neurokinin neurotransmitter, which is characterized by the C-terminal sequence, Phe-X-Gly-Leu-Met-NH2. Substance P is known to be an important part of endocrine and exocrine gland secretion. In addition, Substance P is essential in smooth muscle contraction, pain, inflammatory response including vasodilation, plasma extravasation and mobilization of immune system cells. Alternate studies suggest that Substance P is a key factor in cancer cell proliferation and that inhibition of this component can induce apoptosis in cancer cells and decrease the steady state of Her2 (Neu) and EGFR. Substance P inhibits the phosphorylation of ERK, which results in a reduction of capsaicin-induced nociception. Substance P is an activator of NK-1R.
1. V Euler, U.S. and Gaddum, J.H. 1931. J. Physiol. 72: 74-87. PMID: 16994201 2. Mayordomo, C., et al. 2011. J Cell Physiol. PMID: 21604273 3. Komatsu, T., et al. 2011. Neuropharmacology. [Epub ahead of print]. PMID: 21601581
Solubilize the product in an aqueous buffer or DMSO, then run the solution through a sterile filter to achieve a sterile end product.
Soluble in water (1 mg/ml), DMSO, and 5% Acetic Acid.
Rated 5 out of
Komatsu et alKomatsu et al. (PubMed ID 21601581) found that Substance P inhibited the phosphorylation of ERK and reduced nociceptive response resulting from capsaicin induction. -SCBT Publication Review -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.