Substance P A neurokinin undecapeptide neurotransmitter and neuromodulator

Substance P (CAS 33507-63-0)

Substance P | CAS 33507-63-0 is rated 5.0 out of 5 by 1.
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Application: A neurokinin undecapeptide neurotransmitter and neuromodulator
CAS Number: 33507-63-0
Molecular Weight: 1348
Molecular Formula: C63H98N18O13S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Substance P is a neurokinin neurotransmitter, which is characterized by the C-terminal sequence, Phe-X-Gly-Leu-Met-NH2. Substance P is known to be an important part of endocrine and exocrine gland secretion. In addition, Substance P is essential in smooth muscle contraction, pain, inflammatory response including vasodilation, plasma extravasation and mobilization of immune system cells. Alternate studies suggest that Substance P is a key factor in cancer cell proliferation and that inhibition of this component can induce apoptosis in cancer cells and decrease the steady state of Her2 (Neu) and EGFR. Substance P inhibits the phosphorylation of ERK, which results in a reduction of capsaicin-induced nociception. Substance P is an activator of NK-1R.


References

1. V Euler, U.S. and Gaddum, J.H. 1931. J. Physiol. 72: 74-87. PMID: 16994201
2. Mayordomo, C., et al. 2011. J Cell Physiol. PMID: 21604273
3. Komatsu, T., et al. 2011. Neuropharmacology. [Epub ahead of print]. PMID: 21601581

Usage :
Solubilize the product in an aqueous buffer or DMSO, then run the solution through a sterile filter to achieve a sterile end product.
Physical State :
Solid
Sequence :
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Solubility :
Soluble in water (1 mg/ml), DMSO, and 5% Acetic Acid.
Storage :
Store at -20° C
Density :
1.43 g/cm3
Refractive Index :
n20D 1.66
IC50 :
Neurokinin 1 receptor: IC50 = 0.12 nM (human); Neurokinin 3 receptor: IC50 = 125 nM (human)
Ki Data :
Neurokinin 1 receptor: Ki= 1.1 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WM2660000
PubChem CID :
36511
Merck Index :
14: 8863
MDL Number :
MFCD00076780
EC Number :
251-545-8
Beilstein Registry :
5153552
SMILES :
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N

Download SDS (MSDS)

Certificate of Analysis

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Is the product sterile?

Asked by: chemicalsmg
Thank you for your question. After solubilizing Substance P, sc-201169, in an aqueous buffer or DMSO, run the solution through a sterile filter and the end product will be sterile.
Answered by: TechService7
Date published: 2016-12-21
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Rated 5 out of 5 by from Komatsu et al Komatsu et al. (PubMed ID 21601581) found that Substance P inhibited the phosphorylation of ERK and reduced nociceptive response resulting from capsaicin induction. -SCBT Publication Review -SCBT Publication Review
Date published: 2015-05-05
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