Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide.
1. Zhu, Shoutian., et al., 2009. A small molecule primes embryonic stem cells for differentiation. Cell stem cell. 4(5): 416-26. PMID: 19427291
Soluble in ethanol (slightly), methanol, DMSO (100 mg/ml), DMF, and water (limited).
Store at -20° C
~1.5 g/cm3 (Predicted)
n20D 1.78 (Predicted)
Increases the efficiency of directed differentiation: EC5050 = 0.3 µM (Sox17+ /Sox7- cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
ZhuZhu, S. et al. (PubMed 19427291) found that Stauprimide, an indolocarbazole promoter of embryonic stem cell differentiation, interacts with NEM2 and inhibits its nuclear localization. This leads to down regulation of c-Myc, a key regulator of the pluripotent state. -SCBT Publication Review
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