SRT1720 A selective SIRT1 activator

SRT1720 (CAS 1001645-58-4)

SRT1720 | CAS 1001645-58-4 is rated 5.0 out of 5 by 1.
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Synonym: SRT 1720 Hydrochloride; N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride
Application: A selective SIRT1 activator
CAS Number: 1001645-58-4
Purity: ≥98%
Molecular Weight: 506.02
Molecular Formula: C25H23N7OS•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SRT1720 is an NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM), highly selective for SIRT1 over SIRT2 or SIRT3. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regulate the cell cycle.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (< 1 mg/mL at 25 °C), DMSO (38 mg/mL at 25 °C), and ethanol (< 1 mg/mL at 25 °C).
Storage :
Store at -20° C
Melting Point :
209 °C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25232708
SMILES :
C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl

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SRT1720  Product Citations

See how others have used SRT1720. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25902914  Zhao, K. et al. 2015. J Hematol Oncol. 8: 41.

PMID: # 23726949  Cheng, Y. et al. 2013. Eur. J. Pharmacol. 715: 219-29.

Citations 1 to 2 of 2 total

What concentration should I use SRT1720 at to see activation of SIRT1?

Asked by: ChemSynth123
Thank you for your question. SRT1720 (CAS 1001645-58-4); sc-364624 is a selective SIRT1 activator with an EC50 of 0.16 &mu;M in a cell-free assay.
Answered by: Chemical Support 7
Date published: 2017-03-01

Does SRT1720 works in every species? For example, Rat and Mouse.

Asked by: Joey1012
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Rated 5 out of 5 by from Chen Chen, YX. Et al. (PubMed 26296466) found that the Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE(-/-) mice through inhibition of vascular inflammatory response. -SCBT Publication Review
Date published: 2015-01-26
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