Sp-cAMPSAn activator of phosphotransferase and cAMP-dependent kinase

Sp-cAMPS (CAS 93602-66-5)

Sp-cAMPS | CAS 93602-66-5 is rated 5.0 out of 5 by 1.
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Application: An activator of phosphotransferase and cAMP-dependent kinase
CAS Number: 93602-66-5
Purity: ≥98%
Molecular Weight: 446.5
Molecular Formula: C10H11N5O5PS·C6H16N
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sp-cAMPS, a stimulatory diastereoisomer of adenosine 3',5'-(cyclic)phosphorothioate, has been shown to contain an axial exocyclic sulphur atom. Experiments have noted that this agent binds to holoenzymes, releases its catalytic subunit and activates phosphotransferase and cAMP-dependent protein kinase activity. Additionally, Sp-cAMPS has demonstrated the ability to mimick glucagon-stimulated increases in the level of Ca2+ in hepatocytes.


References

1. Braumann, T., et al. 1986. Biochim. Biophys. Acta. 871: 199-206. PMID: 3011099
2. Connelly, P.A., et al. 1987. J. Biol. Chem. 262: 4324-4332. PMID: 3031072
3. Rothermel, J.D., et al. 1988. Biochem. J. 251: 757-762. PMID: 2843164

Usage :
Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in water (25 mg/mL), DMSO, DMF, and methanol.
Storage :
Store at -20° C
Boiling Point :
641.7° C at 760 mmHg (Predicted)
Optical Activity :
α22/D -25.43°, c = 0.99 in water(lit.)
pK Values :
pKa: 1 (Predicted), pKb: 3.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU7358160
MDL Number :
MFCD01459901
SMILES :
C1(=NC=NC2=C1N=C[N]2C3OC4C(C3O[H])O[P](OC4)(=O)[S-])N([H])[H].[N+](CC)(CC)([H])CC

Download SDS (MSDS)

Certificate of Analysis

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Can this product be stored in solution?

Asked by: hawkeye11
This chemical, Sp-cAMPS (CAS 93602-66-5), can be stored in solutions at -20°C for up to 3 months.
Answered by: Chemical Support 1
Date published: 2017-04-10
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Rated 5 out of 5 by from Menezes Menezes, et al. (PubMed ID 25775606) found that Sp-cAMP counteracts the effect of D1/D5 dopaminergic antagonist SCH 23390 on hippocampal dopamine levels in rats. -SCBT Publication Review
Date published: 2015-02-28
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