Sp-5,6-DCI-cBiMPS is a phosphodiesterase-sensitive cAMP analog and potent activator of PKA (cAMP-dependent protein kinase). It has been tested to be cell permeable and resists hydrolysis from type I, II, and III phosphodiesterases. Observed to stop the aggregation induced by thrombin and initiated protein phosphorylation induced by prostaglandin E1 in human platelets. When applied extracellulary to T84 human colon cancer cells in vitro, Sp-5,6-DCI-cBiMPS was shown to be a potent activator of Cl- secretion. Practical in experiments distinguishing between cAMP and cGMP signal transduction pathways.
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See how others have used Sp-5,6-DCI-cBiMPS. Click on the entry to view the PubMed entry .
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