Sordarin sodium salt A tetracyclic diterpene glycoside antifungal metabolite

Sordarin sodium salt (CAS 463356-00-5)

Sordarin sodium salt | CAS 463356-00-5 is rated 5.0 out of 5 by 1.
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Application: A tetracyclic diterpene glycoside antifungal metabolite
CAS Number: 463356-00-5
Purity: ≥98%
Molecular Weight: 514.58
Molecular Formula: C27H39NaO8
* Refer to Certificate of Analysis for lot specific data (including water content).
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An antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor eEF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

Appearance :
Lyophilized powder
Physical State :
Solid
Derived From :
Sordaria araneosa
Solubility :
Soluble in a minimum of 10 mg/ml water
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23702146
MDL Number :
MFCD08277029
SMILES :
CC1CCC2C1CC3(C4CC2(C3(C(=C4)C(C)C)C(=O)[O-])C=O)COC5C(C(C(C(O5)C)OC)O)O.[Na+]

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Sordarin sodium salt  Product Citations

See how others have used Sordarin sodium salt. Click on the entry to view the PubMed entry .

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PMID: # 25231979  Davydova, E. et al. 2014. The Journal of biological chemistry. 289: 30499-510.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Dom nguez Dom nguez, JM. et al. (PubMed 10428815) reported that Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. -SCBT Publication Review
Date published: 2015-04-25
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