Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain cells. Sodium phenylbutyrate has been reported to cause cell growth arrest at the G1 phase and induce apoptosis through activation of JNK. Studies suggest that Sodium Phenylbutyrate also acts as a chemical chaperone by causing a reduction of the load of mutant and mislocated proteins retained in the endoplasmic reticulum (ER). Other experiments have noted that Sodium Phenylbutyrate demonstrates neuroprotective capabilities by attenuating infarction volume, apoptosis, hemispheric swelling and improving neurological status in a murine model of hypoxia-ischemia. Moreover, this agent has been shown to suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction.
1. Appelskog, I.B., et al. 2004. Int. J. Oncol. 24: 1419-1425. PMID: 15138583 2. Zhang, X., et al. 2004. J. Cell. Biochem. 93: 819-829. PMID: 15389886 3. Qi, X., et al. 2004. Mol. Pharmacol. 66: 899-908. PMID: 15226415 4. Gardian, G., et al. 2005. J. Biol. Chem. 280: 556-563. PMID: 15494404
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Soluble in DMSO (25 mM), water (25 mg/ml), and ethanol.
Store at room temperature
Inhibition of HDAC: Ki= 6.34 µM (human Hela cells nuclear extracts)
pKa: 4.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain cells. According to our technical information: Inhibition of HDAC: Ki= 6.34 µM (human Hela cells nuclear extracts).
산타크루즈에 문의 주셔서 감사합니다.
Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor는 cell에 사용할수 있으며 화학품의 정보에 의하면 Inhibition of HDAC: Ki= 6.34 µM (human Hela cells nuclear extracts).
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