Sodium phenylbutyrate An HDAC inhibitor and caspase activator

Sodium phenylbutyrate (CAS 1716-12-7)

Sodium phenylbutyrate | CAS 1716-12-7 is rated 5.0 out of 5 by 1.
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| See product citations (7)
Synonym: 4-PBA; 4-Phenylbutyric acid
Application: An HDAC inhibitor and caspase activator
CAS Number: 1716-12-7
Purity: ≥98%
Molecular Weight: 186.18
Molecular Formula: C10H11O2·Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Sodium phenylbutyrate sc-200652 1 g $64.00
Sodium phenylbutyrate sc-200652A 10 g $150.00

Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain cells. Sodium phenylbutyrate has been reported to cause cell growth arrest at the G1 phase and induce apoptosis through activation of JNK. Studies suggest that Sodium Phenylbutyrate also acts as a chemical chaperone by causing a reduction of the load of mutant and mislocated proteins retained in the endoplasmic reticulum (ER). Other experiments have noted that Sodium Phenylbutyrate demonstrates neuroprotective capabilities by attenuating infarction volume, apoptosis, hemispheric swelling and improving neurological status in a murine model of hypoxia-ischemia. Moreover, this agent has been shown to suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction.


References

1. Appelskog, I.B., et al. 2004. Int. J. Oncol. 24: 1419-1425. PMID: 15138583
2. Zhang, X., et al. 2004. J. Cell. Biochem. 93: 819-829. PMID: 15389886
3. Qi, X., et al. 2004. Mol. Pharmacol. 66: 899-908. PMID: 15226415
4. Gardian, G., et al. 2005. J. Biol. Chem. 280: 556-563. PMID: 15494404

Usage :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM), water (25 mg/ml), and ethanol.
Storage :
Store at room temperature
Melting Point :
214-216° C
Ki Data :
Inhibition of HDAC: Ki= 6.34 µM (human Hela cells nuclear extracts)
pK Values :
pKa: 4.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CY9057220
PubChem CID :
5258
MDL Number :
MFCD00800247
SMILES :
C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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Sodium phenylbutyrateProduct Citations

See how others have used Sodium phenylbutyrate. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 26999661
Cao, AL. et al. 2016. Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy. Laboratory investigation; a journal of technical methods and pathology.

PMID: # 26546743
Bobak, Y. et al. 2016. Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells. Int. J. Biochem. Cell Biol.. 70: 29-38.

PMID: # 26907328
Zhou, Y. et al. 2016. Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells. Viruses. 8:

PMID: # 26762342
Tao, K. et al. 2016. Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by Attenuating ER Stress. Neuroscience bulletin. 32: 61-9.

PMID: # 26218841
Rekha, RS. et al. 2015. Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages. Autophagy. 11: 1688-99.

PMID: # 24140860
Jiang, W. et al. 2013. Differential regulation of human cathelicidin LL-37 by free fatty acids and their analogs. Peptides. 50: 129-38.

PMID: # 21632108
Yu, W. et al. 2011. Heat shock protein 90 inhibition results in altered downstream signaling of mutant KIT and exerts synergistic effects on Kasumi-1 cells when combining with histone deacetylase inhibitor. Leukemia research. 35: 1212-8.

Citations 1 to 7 of 7 total

카탈로그 번호가 SC-200652 인 sodium phenylbutyrate (4-PBA) 가 cell culture 용으로도 사용할 수 있는 것인지 확인하고 싶습니다.

Asked by: errer4
Thank you for inquiring with Santa Cruz Biotechnology. Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain cells. According to our technical information: Inhibition of HDAC: Ki= 6.34 µM (human Hela cells nuclear extracts). 산타크루즈에 문의 주셔서 감사합니다. Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor는 cell에 사용할수 있으며 화학품의 정보에 의하면 Inhibition of HDAC: Ki= 6.34 µM (human Hela cells nuclear extracts).
Answered by: Technical Support 13
Date published: 2017-02-28
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Rated 5 out of 5 by from An increase in p21 protein expression was An increase in p21 protein expression was observed by WB in Hep G2 cells post treatment with Sodium Phenylbutyrate. -SCBT QC
Date published: 2015-04-08
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