Sodium Orthovanadate An inhibitor of several phosphatases and kinases

Sodium Orthovanadate (CAS 13721-39-6)

Sodium Orthovanadate | CAS 13721-39-6 is rated 4.0 out of 5 by 4.
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| See product citations (92)
Synonym: Decavanadate; Sodium vanadate
Application: An inhibitor of several phosphatases and kinases
CAS Number: 13721-39-6
Purity: ≥99%
Molecular Weight: 183.91
Molecular Formula: Na3O4V
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

Sodium Orthovanadate sc-3540 5 g $19.00
Sodium Orthovanadate sc-3540A 50 g $95.00

Sodium orthovanadate is a commonly used general inhibitor for protein tyrosine phosphatases (PTPs), alkaline phosphatase (ALP), and ATPase. Sodium orthovanadate acts as a competitive inhibitor and is completely reversible upon the addition of EDTA or by dilution. The PTP activities are conveniently separable from the protein phosphoseryl and phosphothreonyl phosphatase (PSP) activities inhibited by fluoride and EDTA. Vanadate is routinely used to preserve the protein tyrosyl phosphorylation state in cells, cell lysates, and protein tyrosine kinase assays. Sodium orthovanadate is also an inhibitor of adenosine kinase (AK) and phosphofructokinase (PFK).


1. Gordon, J.A., 1991. Meth. Enzymol. 201: 477-482. PMID: 1943774
2. Huyer, G., et al. 1997. J. Biol. Chem. 272: 843-851. PMID: 8995372

Usage :
Sodium orthovanadate stock solutions (1 mM or higher, as desired) may be prepared in water with the pH adjusted to pH ~10. To ensure the presence of vanadate monomers, boil the solution until translucent and readjust the pH to 10. The precise concentration of a dilute aqueous solution (pH 10.5) may be determined using the molar extinction coefficient (eM= 3,550 at 260 nm). Orange color observed before boiling is due to decavanadate. At pH 10, decavanadate will slowly depolymerize over several hours to the colorless monovanadate; however, the process is accelerated by boiling.

Store solutions at -20°C.
Appearance :
Physical State :
Solubility :
Soluble in water (50 mg/ml, clear to hazy, colorless to faint yellow solution).
Storage :
Store at room temperature
Melting Point :
850-866° C (lit.)
Boiling Point :
3380° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :
EC Number :
Beilstein Registry :

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Sodium OrthovanadateProduct Citations

See how others have used Sodium Orthovanadate. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 92 total

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Popa, IL. et al. 2016. Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression. J. Biol. Chem..

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Midgley, AC. et al. 2016. 17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation. Aging Cell. 15: 531-41.

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Boriushkin, E. et al. 2016. p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages. Sci Rep. 6: 25013.

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Hall, SR. et al. 2015. Jadomycin breast cancer cytotoxicity is mediated by a copper-dependent, reactive oxygen species-inducing mechanism. Pharmacol Res Perspect. 3: e00110.

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Yang, J. et al. 2015. Differences in Unfolded Protein Response Pathway Activation in the Lenses of Three Types of Cataracts. PLoS ONE. 10: e0130705.

Citations 1 to 10 of 92 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Sodium Orthovanadate, sc-3540, is a white to off-white solid.
Answered by: Chemical Support 4
Date published: 2017-04-21
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Rated 4 out of 5 by from Chemical worked well in our experiments Chemical worked well in our experiments, happy with purchase.
Date published: 2015-06-01
Rated 4 out of 5 by from Sodium Orthovanadate is shown to inhibit Sodium Orthovanadate is shown to inhibit the action of lambda protein phosphatase, thus no change in protein expression p-Cofilin 1 in K-562 cells is observed, when compared to untreated cells. It is a known phosphatase inhibitor for protein tyrosine phosphatases. -SCBT QC
Date published: 2015-05-19
Rated 4 out of 5 by from Worked adequately Worked adequately.
Date published: 2015-04-08
Rated 4 out of 5 by from Working well in the lab Working well in the lab.
Date published: 2015-03-19
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