Sodium Orthovanadate An inhibitor of several phosphatases and kinases

Sodium Orthovanadate (CAS 13721-39-6)

Sodium Orthovanadate | CAS 13721-39-6 is rated 4.0 out of 5 by 4.
  • y_2018, m_10, d_21, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_en_US, sid_3540, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 38ms
  • REVIEWS, PRODUCT
| See product citations (92)
Synonym: Decavanadate; Sodium vanadate
Application: An inhibitor of several phosphatases and kinases
CAS Number: 13721-39-6
Purity: ≥99%
Molecular Weight: 183.91
Molecular Formula: Na3O4V
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Sodium Orthovanadate sc-3540 5 g $19.00
Sodium Orthovanadate sc-3540A 50 g $95.00

Sodium orthovanadate is a commonly used general inhibitor for protein tyrosine phosphatases (PTPs), alkaline phosphatase (ALP), and ATPase. Sodium orthovanadate acts as a competitive inhibitor and is completely reversible upon the addition of EDTA or by dilution. The PTP activities are conveniently separable from the protein phosphoseryl and phosphothreonyl phosphatase (PSP) activities inhibited by fluoride and EDTA. Vanadate is routinely used to preserve the protein tyrosyl phosphorylation state in cells, cell lysates, and protein tyrosine kinase assays. Sodium orthovanadate is also an inhibitor of adenosine kinase (AK) and phosphofructokinase (PFK).


References

1. Gordon, J.A., 1991. Meth. Enzymol. 201: 477-482. PMID: 1943774
2. Huyer, G., et al. 1997. J. Biol. Chem. 272: 843-851. PMID: 8995372

Usage :
Sodium orthovanadate stock solutions (1 mM or higher, as desired) may be prepared in water with the pH adjusted to pH ~10. To ensure the presence of vanadate monomers, boil the solution until translucent and readjust the pH to 10. The precise concentration of a dilute aqueous solution (pH 10.5) may be determined using the molar extinction coefficient (eM= 3,550 at 260 nm). Orange color observed before boiling is due to decavanadate. At pH 10, decavanadate will slowly depolymerize over several hours to the colorless monovanadate; however, the process is accelerated by boiling.

Store solutions at -20°C.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml, clear to hazy, colorless to faint yellow solution).
Storage :
Store at room temperature
Melting Point :
850-866° C (lit.)
Boiling Point :
3380° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YW1120000
PubChem CID :
61671
MDL Number :
MFCD00003511
EC Number :
237-287-9
Beilstein Registry :
12153548
SMILES :
[O-][V](=O)([O-])[O-].[Na+].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

Sodium OrthovanadateProduct Citations

See how others have used Sodium Orthovanadate. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 92 total

PMID: # 28626608  Song, L. et al. 2017. PeerJ. 5: e3418.

PMID: # 26902408  Rahman, N. et al. 2016. Phytomedicine. 23: 58-67.

PMID: # 26981571  Scholz, G. et al. 2016. EBioMedicine. 4: 50-61.

PMID: # 27431816  Nakao, H. et al. 2016. Glycoconj. J.

PMID: # 27053106  Popa, IL. et al. 2016. J. Biol. Chem.

PMID: # 26931423  Midgley, AC. et al. 2016. Aging Cell. 15: 531-41.

PMID: # 26934553  Webber, JP. et al. 2016. Oncotarget.

PMID: # 27113095  Boriushkin, E. et al. 2016. Sci Rep. 6: 25013.

PMID: # 25729577  Hall, SR. et al. 2015. Pharmacol Res Perspect. 3: e00110.

PMID: # 26091066  Yang, J. et al. 2015. PLoS ONE. 10: e0130705.

Citations 1 to 10 of 92 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Sodium Orthovanadate, sc-3540, is a white to off-white solid.
Answered by: Chemical Support 4
Date published: 2017-04-21
  • y_2018, m_10, d_21, h_15CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.8
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_3540, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 228ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Chemical worked well in our experiments Chemical worked well in our experiments, happy with purchase.
Date published: 2015-06-01
Rated 4 out of 5 by from Sodium Orthovanadate is shown to inhibit Sodium Orthovanadate is shown to inhibit the action of lambda protein phosphatase, thus no change in protein expression p-Cofilin 1 in K-562 cells is observed, when compared to untreated cells. It is a known phosphatase inhibitor for protein tyrosine phosphatases. -SCBT QC
Date published: 2015-05-19
Rated 4 out of 5 by from Worked adequately Worked adequately.
Date published: 2015-04-08
Rated 4 out of 5 by from Working well in the lab Working well in the lab.
Date published: 2015-03-19
  • y_2018, m_10, d_21, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_en_US, sid_3540, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.