Sodium dichloroacetate has been shown to have numerous effects on pathways of intermediary metabolism. Experiments have reported the compound to inhibit gluconeogenesis and stimulate peripheral glucose utilization. It has additionally been found to facilitate oxidation of lactate via increase in activity of pyruvate dehydrogenase. This agent also demonstrates the ability to inhibit lipogenesis and cholesterolgenesis, as well as its own metabolism. Furthermore, assays have found sodium dichloroacetate to improve cardiac output and left ventricular mechanical efficiency via facilitation of myocardial metabolism of lactate and carbohydrate as opposed to fat. Other studies suggest that sodium dichloroacetate inhibits tumor growth and may decrease proliferation and induce apoptosis in cancer cell lines. Sodium dichloroacetate is an inhibitor of PDK.
Rated 5 out of
Kimura et alKimura et al. (PubMed ID 9440797) found that sodium dichloroacetate stimulated pyruvate dehydrogenase complex activity and decreased lactic and pyruvic acid concentration in serum and CSF in patients suffering from mitochrondrial encephalomyelopathy. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.