Sodium dichloroacetate An inhibitor of mitochondrial pyruvate dehydrogenase kinase

Sodium dichloroacetate (CAS 2156-56-1)

Synonym: Dichloroacetic Acid Sodium Salt
Application: An inhibitor of mitochondrial pyruvate dehydrogenase kinase
CAS Number: 2156-56-1
Purity: ≥99%
Molecular Weight: 150.92
Molecular Formula: C2HCl2NaO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sodium dichloroacetate has been shown to have numerous effects on pathways of intermediary metabolism. Experiments have reported the compound to inhibit gluconeogenesis and stimulate peripheral glucose utilization. It has additionally been found to facilitate oxidation of lactate via increase in activity of pyruvate dehydrogenase. This agent also demonstrates the ability to inhibit lipogenesis and cholesterolgenesis, as well as its own metabolism. Furthermore, assays have found sodium dichloroacetate to improve cardiac output and left ventricular mechanical efficiency via facilitation of myocardial metabolism of lactate and carbohydrate as opposed to fat. Other studies suggest that sodium dichloroacetate inhibits tumor growth and may decrease proliferation and induce apoptosis in cancer cell lines. Sodium dichloroacetate is an inhibitor of PDK.


References

1. Stacpoole, P.W. 1989. Metab. Clin. Exp. 38: 1124-1144. PMID: 2554095
2. Kimura, S., et al. 1997. Brain Dev. 19: 535-540. PMID: 9440797
3. Bonnet, S., et al. 2007. Cancer Cell. 11: 37-51. PMID: 17222789

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in cold water.
Storage :
Store at room temperature
Melting Point :
198° C (lit.)(dec.)
Boiling Point :
194° C at 760 mmHg
IC50 :
A549 (Lung carcinoma cells): IC50 = 1011 µM (human); Bel7402 cells: IC50 = 860 µM (human); Pyruvate dehydrogenase kinase isoform 1: EC5050 = 130 µM (human); Pyruvate dehydrogenase kinase isoform 2: EC5050 = 130 µM; Pyruvate dehydrogenase kinase isoform 3: EC5050 = 130 µM (human); Pyruvate dehydrogenase kinase isoform 4: EC5050 = 130 µM (human)
pK Values :
pKa: 1.37
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
AG9275000
PubChem CID :
517326
MDL Number :
MFCD00070489
EC Number :
218-461-3
Beilstein Registry :
3916178
SMILES :
C(C(=O)[O-])(Cl)Cl.[Na+]

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How to take sodium dichloroacetate?

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Rated 5 out of 5 by from Kimura et al Kimura et al. (PubMed ID 9440797) found that sodium dichloroacetate stimulated pyruvate dehydrogenase complex activity and decreased lactic and pyruvic acid concentration in serum and CSF in patients suffering from mitochrondrial encephalomyelopathy. -SCBT Publication Review
Date published: 2015-01-18
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