Sodium Citrate, Dihydrate An anticoagulant also used as a biological buffer

Sodium Citrate, Dihydrate (CAS 6132-04-3)

Sodium Citrate, Dihydrate | CAS 6132-04-3 is rated 5.0 out of 5 by 1.
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Synonym: Citric acid trisodium salt dihydrate; Trisodium citrate dihydrate
Application: An anticoagulant also used as a biological buffer
CAS Number: 6132-04-3
Purity: ≥99%
Molecular Weight: 294.10
Molecular Formula: C6H5O72H2O•3Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sodium Citrate, Dihydrate, a conjugate base of a weak acid, can perform as a biological buffering agent because it resists changes in pH. Citric acid is one of a series of compounds responsible for the physiological oxidation of fats, carbohydrates and proteins to carbon dioxide and water. Sodium Citrate, Dihydrate is often used to prepare sodium citrate buffer for antigen retrieval of tissue samples. The citrate solution is designed to break protein cross-links; thus, unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, resulting in enhancing staining intensity of antibodies. Citrate has anticoagulant activity and as a calcium chelator, it forms complexes that disrupt the tendency of blood to clot.
Additional forms available:
Citric Acid Monohydrate (sc-203327)
Citric Acid, Anhydrous (sc-211113)
Citric Acid Trisodium Salt (sc-214745)
Sodium citrate monobasic (sc-215869)
Sodium citrate tribasic hydrate (sc-236898)
Citrate Concentrated Solution (sc-294091)


References

1. Vandemark, P.J. and Smith, P.F. 1964. J. Bacteriol. 88: 1602-1607. PMID: 14240945
2. Shi, S.R., et al. 1993. J. Histochem. Cytochem. 41: 1599-1604. PMID: 7691930
3. Echezarreta, G., et al. 1997. Sangre. 42: 369-375. PMID: 9424736
4. Uszyński, W., et al. 2007. Folia Histochem. Cytobiol. 45: 33-36. PMID: 17378243

Usage :
• For antigen retrieval, prepare a solution of 10 mM sodium citrate buffer, pH 6.0.
Physical State :
Solid
Solubility :
Soluble in water (29.4 g/l) at 20° C. Insoluble in ethanol.
Storage :
Store at room temperature
Melting Point :
>300° C (lit.)
Boiling Point :
309.6° C at 760 mmHg (Predicted)
Density :
1.76 g/cm3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
GE7810000
PubChem CID :
71474
Merck Index :
14: 8602
MDL Number :
MFCD00150031
EC Number :
200-675-3
Beilstein Registry :
6104939
SMILES :
C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.O.O.[Na+].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of Sodium Various publications cite the use of Sodium Citrate in the preparation of citrate buffer for antigen and epitope unmasking in formalin-fixed and paraffin embedded tissue sections. -SCBT Publication Review
Date published: 2015-05-07
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