Sodium Butyrate An HDAC inhibitor and apoptosis inducer

Sodium Butyrate (CAS 156-54-7)

| See product citations (9)
Synonym: Butyric acid sodium salt
Application: An HDAC inhibitor and apoptosis inducer
CAS Number: 156-54-7
Purity: ≥98%
Molecular Weight: 110.09
Molecular Formula: C4H7O2•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). This compound has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally this agent demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.


References

1. Sealy, L., et al., 1978. The effect of sodium butyrate on histone modification. Cell. 14(1): 115-21. PMID: 667928
2. Davie, James R., et al., 2003. Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition. 133(7 Suppl): 2485S-2493S. PMID: 12840228
3. Joseph, Jeena., et al., 2004. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene. 23(37): 6304-15. PMID: 15318170
4. Sekhavat, Anoushe., et al., 2007. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochemistry and cell biology = Biochimie et biologie cellulaire. 85(6): 751-8. PMID: 18059533

Physical State :
Solid
Solubility :
Soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7.2 (~10 mg/ml). Insoluble in ether.
Storage :
Store at -20° C
Melting Point :
250-253° C (lit.)
IC50 :
Histone deacetylase 7: IC50 = 140 µM (human); Histone deacetylase 8: IC50 = 140 µM (human); Histone deacetylase 1: IC50 = 140 µM (human)
Ki Data :
Carbonic anhydrase: Ki= 26.9 µM (Candida albicans ); Carbonic anhydrase I: Ki= 511 µM (human)
pK Values :
pKa: 4.82
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
ET6400000
PubChem CID :
5222465
MDL Number :
MFCD00002816
EC Number :
205-857-6
Beilstein Registry :
3629439
SMILES :
CCCC(=O)[O-].[Na+]

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Sodium Butyrate  Product Citations

See how others have used Sodium Butyrate. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 25342559  Yang, Y. et al. 2014. Cell Res. 24: 1342-53.

PMID: # 17967882  Pesavento, JJ. et al. 2008. Mol. Cell. Biol. 28: 468-486.

PMID: # 17881451  Neumann, DM. et al. 2007. J. Virol. 81: 13248-13253.

PMID: # 16699007  Lu, F. et al. 2006. J. Virol. 80: 5273-5282.

PMID: # 16699007  Lu, F. et al. 2006. J. Virol. 80: 5273-5282.

PMID: # 12654818  Scaife, H. et al. 2003. Infect. Immun. 71: 1995-2001.

PMID: # 11884567  Chiou, CJ. et al. 2002. J. Virol. 76: 3421-3439.

PMID: # 10639456  Gerçeker, AA. et al. 2000. Infect. Immun. 68: 861-870.

PMID: # 9971760  Gasmi, M. et al. 1999. J. Virol. 73: 1828-1834.

Citations 1 to 9 of 9 total
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Rated 5 out of 5 by from Works very well for us Works very well for us- we buy it routinely
Date published: 2015-03-19
Rated 5 out of 5 by from An increase in Ac An increase in Ac-Histone H4 expression observed by WB when comparing untreated and sodium butyrate treated HeLa cells. -SCBT QC
Date published: 2015-01-09
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