Sobuzoxane An inhibitor of DNA topoisomerase II which induces apoptosis

Sobuzoxane (CAS 98631-95-9)

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Synonym: 4,4′-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione); MST-16
Application: An inhibitor of DNA topoisomerase II which induces apoptosis
CAS Number: 98631-95-9
Purity: ≥95%
Molecular Weight: 514.53
Molecular Formula: C22H34N4O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sobuzoxane, a dioxopiperazine, chelates metal cations and reduces the generation of free radicals due to metal-anthracycline complexes. It interacts with topoisomerase II and blocks the formation of topoisomerase II-DNA complex. Sobuzoxane effectively blocks cell proliferation and blocks cells in G2/M phase in selected human tumor cell lines. It protects cardiomyocytes from the cardiotoxicity induced by prolonged doxorubicin treatment.


References

1. Onishi, Y. et al. 1994. Biochem. Mol. Biol. Int. 32(1): 115-122. PMID: 8012276
2. Yoshida, M. et al. 1999. Clin. Cancer Res. 5(12): 4295-4300. PMID: 10632373

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO (19 mg/ml).
Storage :
Store at room temperature
Boiling Point :
~664.92° C at 760 mmHg (Predicted)
Density :
~1.27 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
Antiproliferative activity against mouse neural precursor cells : EC5050 = 10.19 µM
pK Values :
pKb: 2.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
FG1582500
PubChem CID :
5233
Merck Index :
14: 8568
MDL Number :
MFCD00866498
Beilstein Registry :
6031322
SMILES :
CC(C)COC(=O)OCN1C(=O)CN(CCN2CC(=O)N(COC(=O)OCC(C)C)C(=O)C2)CC1=O

Download SDS (MSDS)

Certificate of Analysis

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