SN 38 inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. SN 38 displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively). Active metabolite of CPT-11 (sc-202186) that inhibits DNA Topo I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively).
1. Kawato, Y., et al. 1991. Cancer Res. 51: 4187-4191. 2. Gao, H., et al. 2005. Bioorg. Med. Chem. Lett. 15: 3233-3236. 3. Koizumi, F., et al. 2006. Cancer Res. 66: 10048-10056.
Soluble in DMSO (100 mM).
Store at 4° C
217° C (lit.)
~810.3° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
n20D 1.74 (Predicted)
α20/D -19.2°, c = 0.8 in DMSO; α20/D +21.5°±4.5°, c = 0.2 in THF
Hi, do you have any UV data available for SN-38? Also any solubility information in THF?
Asked by: sgcarmst
Thank you for your question. SN 38 (CAS 86639-52-3) sc-203697 is soluble in DMSO at a concentration of 100 mM. You can download lot-specific certificates of analysis by providing the lot number of the product on its product page.
For further information, or if you have no lot number available, please contact our technical service.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-21
Do you have information about the storage and stability for the SN38 in DMSO ?
Asked by: Jbio
Thank you for your question. We recommend that solutions be used the same day they are made. If you need to store the solution we recommend to aliquot into useable amounts and freeze for up to 1 month. Multiple freeze/thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2017-10-26
Why it is named as SN-38
Asked by: Shilpi Prasad
Thank you for your your question. This chemical has been assigned CAS number 86639-52-3 and is known by many alternate names including SN 38, and 7-Ethyl-10-hydroxycamptothecin. We do not have any information about how it was named.
Rated 5 out of
Bon produit conforme aux attentesproduit acheté suite à une rupture de stock de notre fournisseur et très satisfait du résultat qui fut conforme aux attentes. les résultats obtenus étaient similaire à notre autre référence. de plus livraison extrêmement rapide!
Date published: 2017-10-23
Rated 5 out of
Routinely use this in our labRoutinely use this in our lab, always works well for us.
Date published: 2015-03-13
Rated 5 out of
An increase in p21 protein expression wasAn increase in p21 protein expression was observed by WB in HCT 116 cells after treatment with SN 38. -SCBT QC
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