SN 38 The active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)

SN 38 (CAS 86639-52-3)

SN 38 | CAS 86639-52-3 is rated 5.0 out of 5 by 3.
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Synonym: 7-Ethyl-10-hydroxycamptothecin
Application: The active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)
CAS Number: 86639-52-3
Purity: ≥98%
Molecular Weight: 392.41
Molecular Formula: C22H20N2O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

SN 38 inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. SN 38 displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively). Active metabolite of CPT-11 (sc-202186) that inhibits DNA Topo I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively).


References

1. Kawato, Y., et al. 1991. Cancer Res. 51: 4187-4191.
2. Gao, H., et al. 2005. Bioorg. Med. Chem. Lett. 15: 3233-3236.
3. Koizumi, F., et al. 2006. Cancer Res. 66: 10048-10056.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
217° C (lit.)
Boiling Point :
~810.3° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
Optical Activity :
α20/D -19.2°, c = 0.8 in DMSO; α20/D +21.5°±4.5°, c = 0.2 in THF
IC50 :
HCT-116: IC50 = 3.3 nM (human); BEL-7402: IC50 = 13 nM (human); HL60: IC50 = 19 nM (human); HELA cell: IC50 = 22 nM (human); DNA synthesis: IC50 = 0.077 µM
Ki Data :
CYP3A4: Ki= 26 µM (human)
pK Values :
pKa: 9.13 (Predicted), pKb: 5.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UQ0491000
PubChem CID :
104842
MDL Number :
MFCD06762720
SMILES :
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O

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Certificate of Analysis

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SN 38  Product Citations

See how others have used SN 38. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28484907  Kong, TY. et al. 2017. Arch. Pharm. Res. 40: 727-735.

PMID: # 27128896  Kwon, SS. et al. 2016. Molecules. 21:

PMID: # 25904760  Lee, B. et al. 2015. Drug Metab. Dispos. 43: 1137-46.

PMID: # 26364932  Wallace, BD. et al. 2015. Chemistry & biology. 22: 1238-49.

PMID: # 25522350  Joo, J. et al. 2015. Biopharm Drug Dispos. 36: 258-64.

PMID: # 25303469  Joo, J. et al. 2014. Rapid Commun. Mass Spectrom. 28: 2405-14.

Citations 1 to 6 of 6 total

Hi, do you have any UV data available for SN-38? Also any solubility information in THF?

Asked by: sgcarmst
Thank you for your question. SN 38 (CAS 86639-52-3) sc-203697 is soluble in DMSO at a concentration of 100 mM. You can download lot-specific certificates of analysis by providing the lot number of the product on its product page. For further information, or if you have no lot number available, please contact our technical service.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-21

Do you have information about the storage and stability for the SN38 in DMSO ?

Asked by: Jbio
Thank you for your question. We recommend that solutions be used the same day they are made. If you need to store the solution we recommend to aliquot into useable amounts and freeze for up to 1 month. Multiple freeze/thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2017-10-26

Why it is named as SN-38

Asked by: Shilpi Prasad
Thank you for your your question. This chemical has been assigned CAS number 86639-52-3 and is known by many alternate names including SN 38, and 7-Ethyl-10-hydroxycamptothecin. We do not have any information about how it was named.
Answered by: Technical Support
Date published: 2017-08-21
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Rated 5 out of 5 by from Bon produit conforme aux attentes produit acheté suite à une rupture de stock de notre fournisseur et très satisfait du résultat qui fut conforme aux attentes. les résultats obtenus étaient similaire à notre autre référence. de plus livraison extrêmement rapide!
Date published: 2017-10-23
Rated 5 out of 5 by from Routinely use this in our lab Routinely use this in our lab, always works well for us.
Date published: 2015-03-13
Rated 5 out of 5 by from An increase in p21 protein expression was An increase in p21 protein expression was observed by WB in HCT 116 cells after treatment with SN 38. -SCBT QC
Date published: 2015-02-11
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